구아닌 뉴클레오티드 결합 단백질 G(z) 서브유닛 알파 는 인간에서 닐즈 유전자 에 의해 인코딩 되는 단백질이다.[5] [6]
함수 이 유전자에 의해 암호화된 단백질은 백일해독성 민감성 시스템에서 신호 전달을 매개하는 G단백질 하위 계열의 일원이다. 이 인코딩된 단백질은 경혈성 달팽이관 액체와 종양성 달팽이관 액체의 이온 균형을 유지하는 역할을 할 수 있다.[6]
상호작용 닐츠는 EYA2 , [7] RGS20 [8] [9] RGS19 와 상호작용 하는 것으로 나타났다.[7] [10]
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Chem . 275 (41): 32129–34. doi :10.1074/jbc.M004577200 PMID 10906137 . ^ Nagahama M, Usui S, Shinohara T, Yamaguchi T, Tani K, Tagaya M (December 2002). "Inactivation of Galpha(z) causes disassembly of the Golgi apparatus" . J. Cell Sci . 115 (Pt 23): 4483–93. doi :10.1242/jcs.00093 PMID 12414994 . ^ Glick JL, Meigs TE, Miron A, Casey PJ (October 1998). "RGSZ1, a Gz-selective regulator of G protein signaling whose action is sensitive to the phosphorylation state of Gzalpha" . J. Biol. Chem . 273 (40): 26008–13. doi :10.1074/jbc.273.40.26008 PMID 9748279 . ^ De Vries L, Elenko E, Hubler L, Jones TL, Farquhar MG (December 1996). "GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits" . Proc. Natl. Acad. Sci. U.S.A . 93 (26): 15203–8. 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"Chromosomal localization of genes encoding guanine nucleotide-binding protein subunits in mouse and human" . Proc. Natl. Acad. Sci. U.S.A . 85 (20): 7642–6. Bibcode :1988PNAS...85.7642B . doi :10.1073/pnas.85.20.7642 PMC 282248 PMID 2902634 . Fong HK, Yoshimoto KK, Eversole-Cire P, Simon MI (1988). "Identification of a GTP-binding protein alpha subunit that lacks an apparent ADP-ribosylation site for pertussis toxin" . Proc. Natl. Acad. Sci. U.S.A . 85 (9): 3066–70. Bibcode :1988PNAS...85.3066F . doi :10.1073/pnas.85.9.3066 PMC 280144 PMID 3129724 . Fields TA, Casey PJ (1995). "Phosphorylation of Gz alpha by protein kinase C blocks interaction with the beta gamma complex" . J. Biol. Chem . 270 (39): 23119–25. doi :10.1074/jbc.270.39.23119 PMID 7559455 . Lounsbury KM, Schlegel B, Poncz M, Brass LF, Manning DR (1993). "Analysis of Gz alpha by site-directed mutagenesis. Sites and specificity of protein kinase C-dependent phosphorylation" . J. Biol. 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"GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits" . Proc. Natl. Acad. Sci. U.S.A . 93 (26): 15203–8. Bibcode :1996PNAS...9315203D . doi :10.1073/pnas.93.26.15203 PMC 26381 PMID 8986788 . Ho MK, Wong YH (1997). "Functional role of amino-terminal serine16 and serine27 of G alphaZ in receptor and effector coupling" . J. Neurochem . 68 (6): 2514–22. doi :10.1046/j.1471-4159.1997.68062514.x PMID 9166747 . Sidhu A, Kimura K, Uh M, White BH, Patel S (1998). "Multiple coupling of human D5 dopamine receptors to guanine nucleotide binding proteins Gs and Gz" . J. Neurochem . 70 (6): 2459–67. doi :10.1046/j.1471-4159.1998.70062459.x PMID 9603210 . Lin P, Le-Niculescu H, Hofmeister R, McCaffery JM, Jin M, Hennemann H, McQuistan T, De Vries L, Farquhar MG (1998). "The mammalian calcium-binding protein, nucleobindin (CALNUC), is a Golgi resident protein" . J. Cell Biol . 141 (7): 1515–27. doi :10.1083/jcb.141.7.1515 . 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