구아닌 뉴클레오티드 결합 단백질 G(I)/G(S)/G(O) 서브유닛 감마-T2 는 인간에서 GNGT2 유전자 에 의해 인코딩되는 단백질 이다.[5] [6]
로드와 콘 광수용체에서의 광전도는 신호 단백질 그룹에 의해 조절된다. 인코딩된 단백질은 원뿔 광전도에 결정적인 역할을 하는 것으로 생각된다. G단백질 감마과에 속하며 특히 원추에 국부화된다. 이 유전자에 의한 다중 폴리아데닐화 부위의 사용에 대한 증거가 있다.[6]
참조 추가 읽기 Cohen NA, Sha Q, Makhina EN, et al. (1997). "Inhibition of an inward rectifier potassium channel (Kir2.3) by G-protein betagamma subunits" . J. Biol. Chem . 271 (50): 32301–5. doi :10.1074/jbc.271.50.32301 PMID 8943291 . Huang CL, Jan YN, Jan LY (1997). "Binding of the G protein betagamma subunit to multiple regions of G protein-gated inward-rectifying K+ channels" . FEBS Lett . 405 (3): 291–8. doi :10.1016/S0014-5793(97)00197-X PMID 9108307 . S2CID 44072628 . Cook LA, Schey KL, Cleator JH, et al. (2002). "Identification of a region in G protein γ subunits conserved across species but hypervariable among subunit isoforms" . Protein Sci . 10 (12): 2548–55. doi :10.1110/ps.ps.26401 . PMC 2374038 PMID 11714923 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Cuello F, Schulze RA, Heemeyer F, et al. (2003). "Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Complex formation of NDPK B with Gbeta gamma dimers and phosphorylation of His-266 IN Gbeta" . J. Biol. Chem . 278 (9): 7220–6. doi :10.1074/jbc.M210304200 PMID 12486123 . Ivanina T, Rishal I, Varon D, et al. (2003). "Mapping the Gbetagamma-binding sites in GIRK1 and GIRK2 subunits of the G protein-activated K+ channel" . J. Biol. Chem . 278 (31): 29174–83. doi :10.1074/jbc.M304518200 PMID 12743112 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . DePuy SD, Yao J, Hu C, et al. (2006). "The molecular basis for T-type Ca2+ channel inhibition by G protein β2γ2 subunits" . Proc. Natl. Acad. Sci. U.S.A . 103 (39): 14590–5. Bibcode :2006PNAS..10314590D . doi :10.1073/pnas.0603945103 PMC 1600004 PMID 16973746 .