L-741,626

L-741,626
L-741,626
L-741,626.svg
임상자료
ATC 코드
  • 없는
식별자
  • 3-[4-(4-클로로페닐)-4-히드록시피페리딘-l-yl]메틸-1H-indole
CAS 번호
펍켐 CID
IUPHAR/BPS
켐스파이더
CompTox 대시보드 (EPA)
화학 및 물리적 데이터
공식C20H21CLN2O
어금질량340.85 g·190−1
3D 모델(JSmol)
  • OC(CC1)(C2=CC=C(Cl)2)CCN1CC3=CNC4=CC=CC43
  • InChI=1S/C20H21ClN2O/c21-17-7-5-16(6-8-17)20(24)9-11-23(12-10-20)14-15-13-22-19-4-2-1-3-18(15)19/h1-8,13,22,24H,9-12,14H2 ☒N
  • 키:LLBLNMUONVPG-UHFFFAOYSA-N ☒N
☒NcheckY (이게 뭐야?) (iii)

L-741,626은 도파민 수용체 D의2 강력한 선택적 길항제 역할을 하는 약물이다.관련 D3 및 D4 하위유형 및 기타 수용체에 비해 선택성이 좋다.L-741,626은 뇌 기능에 대한 실험실 연구에 사용되며, 특히 D 매개2 반응을 D 하위 유형과 밀접하게 관련된 D 하위3 유형에서 생성되는 반응과 구별하고, 뇌에서 코카인과 암페타민의 작용에서 이러한 하위 유형의 역할을 연구하는 데 유용하다는 것이 입증되었다.[1][2][3][4][5][6][7][8][9][10]

참조

  1. ^ Bowery BJ, Razzaque Z, Emms F, Patel S, Freedman S, Bristow L, Kulagowski J, Seabrook GR (December 1996). "Antagonism of the effects of (+)-PD 128907 on midbrain dopamine neurones in rat brain slices by a selective D2 receptor antagonist L-741,626". British Journal of Pharmacology. 119 (7): 1491–7. doi:10.1111/j.1476-5381.1996.tb16063.x. PMC 1915834. PMID 8968560.
  2. ^ Canales JJ, Iversen SD (September 2000). "Psychomotor-activating effects mediated by dopamine D(2) and D(3) receptors in the nucleus accumbens". Pharmacology Biochemistry and Behavior. 67 (1): 161–8. doi:10.1016/S0091-3057(00)00311-7. PMID 11113496. S2CID 26640822.
  3. ^ Costanza RM, Barber DJ, Terry P (November 2001). "Antagonism of the discriminative stimulus effects of cocaine at two training doses by dopamine D2-like receptor antagonists". Psychopharmacology. 158 (2): 146–53. doi:10.1007/s002130100872. PMID 11702088. S2CID 22530289.
  4. ^ Chaperon F, Tricklebank MD, Unger L, Neijt HC (June 2003). "Evidence for regulation of body temperature in rats by dopamine D2 receptor and possible influence of D1 but not D3 and D4 receptors". Neuropharmacology. 44 (8): 1047–53. doi:10.1016/S0028-3908(03)00113-8. PMID 12763098. S2CID 19219652.
  5. ^ Grundt P, Husband SL, Luedtke RR, Taylor M, Newman AH (February 2007). "Analogues of the dopamine D2 receptor antagonist L741,626: Binding, function, and SAR". Bioorganic & Medicinal Chemistry Letters. 17 (3): 745–9. doi:10.1016/j.bmcl.2006.10.076. PMC 1851912. PMID 17095222.
  6. ^ Koffarnus MN, Greedy B, Husbands SM, Grundt P, Newman AH, Woods JH (April 2009). "The discriminative stimulus effects of dopamine D2- and D3-preferring agonists in rats". Psychopharmacology. 203 (2): 317–27. doi:10.1007/s00213-008-1323-4. PMC 3065021. PMID 18807248.
  7. ^ Depoortère R, Bardin L, Rodrigues M, Abrial E, Aliaga M, Newman-Tancredi A (July 2009). "Penile erection and yawning induced by dopamine D2-like receptor agonists in rats: influence of strain and contribution of dopamine D2, but not D3 and D4 receptors". Behavioural Pharmacology. 20 (4): 303–11. doi:10.1097/FBP.0b013e32832ec5aa. PMID 19584712. S2CID 35558814.
  8. ^ Fan X, Xu M, Hess EJ (January 2010). "D2 dopamine receptor subtype-mediated hyperactivity and amphetamine responses in a model of ADHD". Neurobiology of Disease. 37 (1): 228–36. doi:10.1016/j.nbd.2009.10.009. PMC 2839459. PMID 19840852.
  9. ^ Achat-Mendes C, Grundt P, Cao J, Platt DM, Newman AH, Spealman RD (August 2010). "Dopamine D3 and D2 receptor mechanisms in the abuse-related behavioral effects of cocaine: studies with preferential antagonists in squirrel monkeys". The Journal of Pharmacology and Experimental Therapeutics. 334 (2): 556–65. doi:10.1124/jpet.110.167619. PMC 2913766. PMID 20494958.
  10. ^ Watson DJ, Marsden CA, Millan MJ, Fone KC (March 2011). "Blockade of dopamine D3 but not D2 receptors reverses the novel object discrimination impairment produced by post-weaning social isolation: implications for schizophrenia and its treatment". The International Journal of Neuropsychopharmacology. 15 (4): 471–484. doi:10.1017/S1461145711000435. PMID 21414250.


Stub icon

신경계통에 관한 이 약물 기사는 단조롭다.위키피디아를 확장하여 도울 수 있다.