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87 stars written in C
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A new bootable USB solution.

C 75,875 4,750 Updated Apr 14, 2026

Command-line JSON processor

C 34,450 1,767 Updated Apr 13, 2026

Extremely Fast Compression algorithm

C 11,765 1,535 Updated Apr 1, 2026

The future of online communications.

C 8,755 1,291 Updated Jul 13, 2024

Open Source Soldering Iron firmware

C 8,145 801 Updated Apr 12, 2026

Run arbitrary commands when files change

C 5,541 121 Updated Mar 2, 2026

Vim - the text editor - for Mac OS X

C 5,054 390 Updated Aug 5, 2017

High Performance Open Source Radio Control Link

C 4,862 1,372 Updated Apr 15, 2026

A novel data compression framework

C 2,993 140 Updated Apr 15, 2026

A versatile pairwise aligner for genomic and spliced nucleotide sequences

C 2,155 458 Updated Apr 14, 2026

Toolkit for processing sequences in FASTA/Q formats

C 1,535 328 Updated Jun 1, 2025

Python module (C extension and plain python) implementing Aho-Corasick algorithm

C 1,097 142 Updated Dec 17, 2025

Intelligent Storage Acceleration Library

C 1,068 340 Updated Mar 20, 2026

scaling, counting, bloom filter library

C 967 115 Updated Oct 26, 2019

De novo assembler for single molecule sequencing reads using repeat graphs

C 917 178 Updated Apr 3, 2026

This is the official development repository for BCFtools. See installation instructions and other documentation here http://samtools.github.io/bcftools/howtos/install.html

C 857 269 Updated Apr 7, 2026

OpenZFS on OS X

C 837 73 Updated Apr 7, 2020

Universal Python binding for the LMDB 'Lightning' Database

C 740 118 Updated Apr 9, 2026

Creates a graph of dependencies from GNU-Make; Output is a graphiz-dot file or a Gexf-XML file.

C 665 67 Updated Mar 22, 2025

BWK awk modified for biological data

C 639 117 Updated Aug 11, 2022

Python bindings to the Zstandard (zstd) compression library

C 627 112 Updated Sep 14, 2025

Redbean: A fuzzy Bruijn graph approach to long noisy reads assembly

C 530 93 Updated Sep 27, 2023

RAxML Next Generation: faster, easier-to-use and more flexible

C 463 68 Updated Apr 10, 2026

.DS_Store is an abomination and must be stopped.

C 402 28 Updated Mar 19, 2018

Align proteins to genomes with splicing and frameshift

C 398 21 Updated Jan 5, 2026

HTTP request/response parser for python in C

C 346 96 Updated May 21, 2024

GenomeTools genome analysis system.

C 334 63 Updated Nov 10, 2025

Long read / genome alignment software

C 313 31 Updated Dec 16, 2025

Fast taxonomic classification of metagenomic sequencing reads using a protein reference database

C 302 70 Updated Apr 25, 2025
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