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48 stars written in C++
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A library that provides an embeddable, persistent key-value store for fast storage.

C++ 31,528 6,731 Updated Feb 9, 2026

The MongoDB Database

C++ 28,048 5,754 Updated Feb 10, 2026

A cross-platform, reimplementation of Notepad++

C++ 13,398 810 Updated Feb 7, 2026

A tiny, hackable BitTorrent client.

C++ 2,745 194 Updated Jul 10, 2024

An ultra-fast all-in-one FASTQ preprocessor (QC/adapters/trimming/filtering/splitting/merging...)

C++ 2,281 371 Updated Jan 22, 2026

tools for working with genome variation graphs

C++ 1,296 214 Updated Feb 9, 2026

Accelerated BLAST compatible local sequence aligner.

C++ 1,237 187 Updated Feb 7, 2026

🐟 🍣 🍱 Highly-accurate & wicked fast transcript-level quantification from RNA-seq reads using selective alignment

C++ 859 184 Updated May 29, 2024

The next version of bwa-mem

C++ 816 120 Updated Oct 15, 2025

The codebase of the OpenMS project

C++ 562 380 Updated Feb 9, 2026

Graph-based alignment (Hierarchical Graph FM index)

C++ 526 129 Updated Jan 27, 2026

Transcript assembly and quantification for RNA-Seq

C++ 486 86 Updated Dec 26, 2025

RSEM: accurate quantification of gene and isoform expression from RNA-Seq data

C++ 460 126 Updated Mar 13, 2024

Structural variant and indel caller for mapped sequencing data

C++ 458 154 Updated Oct 11, 2025

DIA-NN - a universal automated software suite for DIA proteomics data analysis.

C++ 420 72 Updated Feb 5, 2026

Strelka2 germline and somatic small variant caller

C++ 389 107 Updated Dec 29, 2021

期刊分区查询小工具,包括中科院分区表升级版(2025、2023、2022)及国际期刊预警名单(2025、2024、2023、2021、2020)、JCR(2023、2022、2021、2020)、CCF推荐国际会议和期刊目录(2022)、计算领域高质量科技期刊分级目录(2022)。

C++ 347 38 Updated Jul 22, 2025
C++ 290 61 Updated Oct 24, 2025

Multiple sequence and structure alignment with top benchmark scores scalable to thousands of sequences. Generates replicate alignments, enabling assessment of downstream analyses such as trees and …

C++ 268 28 Updated Dec 22, 2025

Scaling Single Cell Analysis to Millions of Cells

C++ 257 30 Updated Jan 13, 2026

Scissor package

C++ 250 41 Updated May 10, 2024

Ultra-fast preprocessing and quality control for long-read sequencing data

C++ 219 14 Updated Sep 6, 2025

Population-scale genotyping using pangenome graphs

C++ 195 22 Updated Jan 9, 2025

The new source code of the LinearFold, linear-time prediction for RNA secondary structures

C++ 188 51 Updated Apr 4, 2024

Rare variant test software for next generation sequencing data

C++ 141 43 Updated Jan 26, 2022

Microsatellite Instability (MSI) detection using high-throughput sequencing data.

C++ 115 24 Updated Apr 2, 2025

Long read aligner

C++ 114 8 Updated May 26, 2023

Genome mapping and spliced alignment of cDNA or amino acid sequences

C++ 110 15 Updated Jan 26, 2026

An R package for performing STAAR procedure in whole-genome sequencing studies

C++ 97 47 Updated Feb 9, 2025
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