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295 stars written in C++
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Raw nanopore signal mapper that enables real-time targeted sequencing

C++ 531 45 Updated Mar 5, 2024

A fast multi-threaded k-mer counter

C++ 517 138 Updated Mar 20, 2024

Reliable Allreduce and Broadcast Interface for distributed machine learning

C++ 512 182 Updated Nov 5, 2020

SeqAn's official repository.

C++ 497 172 Updated Sep 8, 2025

Transcript assembly and quantification for RNA-Seq

C++ 472 85 Updated Oct 22, 2025

RSEM: accurate quantification of gene and isoform expression from RNA-Seq data

C++ 454 125 Updated Mar 13, 2024

GFF/GTF utility providing format conversions, region filtering, FASTA sequence extraction and more

C++ 443 42 Updated Dec 26, 2024

The modern C++ library for sequence analysis. Contains version 3 of the library and API docs.

C++ 441 86 Updated Oct 28, 2025

RAxML Next Generation: faster, easier-to-use and more flexible

C++ 440 63 Updated Oct 31, 2025

Fast Whole-Genome Similarity (ANI) Estimation

C++ 435 69 Updated Jul 24, 2025

C++ API & command-line toolkit for working with BAM data

C++ 429 156 Updated May 18, 2025

Fast genome and metagenome distance estimation using MinHash

C++ 424 94 Updated Sep 19, 2025

Turning geospatial polygons into regular or hexagonal grids. For other similar functionality see the tilemaps package https://github.com/kaerosen/tilemaps

C++ 403 31 Updated Apr 27, 2023

LabPlot is a FREE, open source and cross-platform Data Visualization and Analysis software accessible to everyone.

C++ 396 55 Updated Nov 9, 2025

Genome browser and variant annotation

C++ 384 10 Updated Oct 30, 2025

adapter trimmer for Oxford Nanopore reads

C++ 375 133 Updated May 8, 2024

quality filtering tool for long reads

C++ 374 29 Updated Sep 17, 2025

AMRFinderPlus - Identify AMR genes and point mutations, and virulence and stress resistance genes in assembled bacterial nucleotide and protein sequence.

C++ 331 47 Updated Sep 26, 2025

🔬 Assemble large genomes using short reads

C++ 326 110 Updated Mar 27, 2025

Bracken (Bayesian Reestimation of Abundance with KrakEN) is a highly accurate statistical method that computes the abundance of species in DNA sequences from a metagenomics sample.

C++ 322 54 Updated Feb 26, 2025

Pixel-art map visualizer for Minecraft. Maps are drawn from an isometric perspective.

C++ 322 45 Updated Mar 9, 2025

Genome annotation with AUGUSTUS

C++ 321 116 Updated Aug 15, 2025

Bayesian haplotype-based mutation calling

C++ 319 36 Updated Oct 1, 2025

Fast and frugal disk based k-mer counter

C++ 309 78 Updated Nov 7, 2025

Scalable Nucleotide Alignment Program -- a fast and accurate read aligner for high-throughput sequencing data

C++ 295 63 Updated Sep 6, 2025

Ultrafast consensus module for raw de novo genome assembly of long uncorrected reads. http://genome.cshlp.org/content/early/2017/01/18/gr.214270.116 Note: This was the original repository which wil…

C++ 290 51 Updated May 9, 2024

A fast approximate aligner for long DNA sequences

C++ 284 39 Updated Oct 11, 2024

Ruby language bindings for LIBSVM

C++ 279 34 Updated Dec 7, 2023

SortMeRNA: next-generation sequence filtering and alignment tool

C++ 277 65 Updated Aug 18, 2025
C++ 277 33 Updated Jul 25, 2025