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30 stars written in C++
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The new Windows Terminal and the original Windows console host, all in the same place!

C++ 102,592 9,197 Updated Apr 9, 2026

Windows Subsystem for Linux

C++ 31,737 1,677 Updated Apr 9, 2026

The Fast Cross-Platform Package Manager

C++ 7,985 438 Updated Apr 8, 2026

An ultra-fast all-in-one FASTQ preprocessor (QC/adapters/trimming/filtering/splitting/merging...)

C++ 2,323 371 Updated Apr 8, 2026

Accelerated BLAST compatible local sequence aligner.

C++ 1,279 189 Updated Mar 28, 2026

SPAdes Genome Assembler

C++ 924 159 Updated Mar 17, 2026

The second version of the Kraken taxonomic sequence classification system

C++ 889 301 Updated Apr 1, 2026

Bayesian haplotype-based genetic polymorphism discovery and genotyping.

C++ 865 275 Updated Feb 8, 2026

Oxford Nanopore's Basecaller

C++ 813 117 Updated Feb 19, 2026

a Bioinformatics Application for Navigating De novo Assembly Graphs Easily

C++ 669 114 Updated Dec 3, 2022

hybrid assembly pipeline for bacterial genomes

C++ 635 138 Updated Jul 25, 2024

Mummer alignment tool

C++ 554 111 Updated Feb 4, 2025

GFF/GTF utility providing format conversions, region filtering, FASTA sequence extraction and more

C++ 469 44 Updated Mar 15, 2026

Fast genome and metagenome distance estimation using MinHash

C++ 438 94 Updated Sep 19, 2025

quality filtering tool for long reads

C++ 397 30 Updated Sep 17, 2025

Bracken (Bayesian Reestimation of Abundance with KrakEN) is a highly accurate statistical method that computes the abundance of species in DNA sequences from a metagenomics sample.

C++ 341 57 Updated Mar 16, 2026

IQ-TREE software version 2: phylogenetics by maximum likelihood

C++ 328 69 Updated Mar 12, 2026

Ultrafast consensus module for raw de novo genome assembly of long uncorrected reads. http://genome.cshlp.org/content/early/2017/01/18/gr.214270.116 Note: This was the original repository which wil…

C++ 297 53 Updated May 9, 2024

[MOVED] Moved to paoloshasta/shasta. De novo assembly from Oxford Nanopore reads

C++ 273 60 Updated Oct 13, 2022

A tool for automated alignment trimming in large-scale phylogenetic analyses. Development version: 2.0

C++ 255 47 Updated Apr 8, 2026

Ultrafast consensus module for raw de novo genome assembly of long uncorrected reads

C++ 239 33 Updated Dec 29, 2023

Accurate Species Tree EstimatoR: a family of optimation algorithms for species tree inference (including ASTRAL & CASTER)

C++ 236 19 Updated Mar 27, 2026

De novo genome assembler for long uncorrected reads

C++ 231 19 Updated Nov 15, 2023

Efficient phylogenomic software by maximum likelihood

C++ 208 45 Updated Nov 4, 2021

Parsnp was designed to align the core genome of hundreds to thousands of bacterial genomes within a few minutes to few hours. Input can be both draft assemblies and finished genomes, and output inc…

C++ 154 27 Updated Oct 2, 2025

ClonalFrameML: Efficient Inference of Recombination in Whole Bacterial Genomes

C++ 121 28 Updated May 21, 2024

Bifrost graph gene caller.

C++ 98 6 Updated Mar 29, 2026

Hitting associations with k-mers

C++ 44 20 Updated May 14, 2022

A whole-genome and alignment-free prokaryotic phylogeny tool

C++ 23 5 Updated Mar 9, 2025

Program for finding horizontal gene transfer using BLAST result

C++ 11 5 Updated May 26, 2023