칼륨 내정 채널인 서브 패밀리 J, 멤버 4 는 KCNJ4 나 K2ir .3 으로도 알려져 있는 인간의 유전자 다.[5]
함수 여러 가지 다른 칼륨 채널이 신경계의 전기 신호와 관련된 것으로 알려져 있다. 한 클래스는 탈극화에 의해 활성화되는 반면 두 번째 클래스는 그렇지 않다. 후자를 내적으로 정류 K+ 채널이라고 하며, 칼륨이 세포 밖으로 흐르기는커녕 세포 안으로 흐르도록 하는 경향이 더 크다. 칼륨 이온 전도성의 이 비대칭은 근육 세포와 뉴런의 흥분성에 중요한 역할을 한다. 이 유전자에 의해 인코딩된 단백질은 일체형 막 단백질이며 내부 정류기 칼륨 채널 계열의 구성원이다. 인코딩된 단백질은 이 단백질 계열의 다른 구성원에 비해 작은 단일 전도성을 가지고 있다. 이 유전자에 대해 동일한 단백질을 인코딩하는 두 개의 대본변형이 발견되었다.[5]
상호작용 KCNJ4는 다음과 상호 작용하는 것으로 나타났다.
참고 항목 참조 ^ a b c GRCh38: 앙상블 릴리스 89: ENSG00000168135 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG000044216 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b "Entrez Gene: KCNJ4 potassium inwardly-rectifying channel, subfamily J, member 4" .^ a b c Leonoudakis D, Conti LR, Anderson S, Radeke CM, McGuire LM, Adams ME, Froehner SC, Yates JR, Vandenberg CA (May 2004). "Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins" . J. Biol. Chem . 279 (21): 22331–46. doi :10.1074/jbc.M400285200 PMID 15024025 . ^ a b c d Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA (April 2004). "A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels" . J. Biol. Chem . 279 (18): 19051–63. doi :10.1074/jbc.M400284200 PMID 14960569 . ^ Leonoudakis D, Mailliard W, Wingerd K, Clegg D, Vandenberg C (March 2001). "Inward rectifier potassium channel Kir2.2 is associated with synapse-associated protein SAP97" . J. Cell Sci . 114 (Pt 5): 987–98. doi :10.1242/jcs.114.5.987 PMID 11181181 . ^ Nehring RB, Wischmeyer E, Döring F, Veh RW, Sheng M, Karschin A (January 2000). "Neuronal inwardly rectifying K(+) channels differentially couple to PDZ proteins of the PSD-95/SAP90 family" . J. Neurosci . 20 (1): 156–62. doi :10.1523/JNEUROSCI.20-01-00156.2000 PMC 6774109 PMID 10627592 . ^ Inanobe A, Fujita A, Ito M, Tomoike H, Inageda K, Kurachi Y (June 2002). "Inward rectifier K+ channel Kir2.3 is localized at the postsynaptic membrane of excitatory synapses". Am. J. Physiol., Cell Physiol . 282 (6): C1396–403. doi :10.1152/ajpcell.00615.2001 . PMID 11997254 . ^ Olsen O, Liu H, Wade JB, Merot J, Welling PA (January 2002). "Basolateral membrane expression of the Kir 2.3 channel is coordinated by PDZ interaction with Lin-7/CASK complex". Am. J. Physiol., Cell Physiol . 282 (1): C183–95. doi :10.1152/ajpcell.00249.2001 . PMID 11742811 .
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