CYP2A7(사이토크롬 P450, 패밀리 2, 하위 패밀리 A, 폴리펩타이드 7)은 인간에서 CYP2A7유전자에 의해 인코딩되는 단백질이다.[5][6]
이 유전자는 효소의 시토크롬 P450 슈퍼패밀리의 구성원을 암호로 한다.시토크롬 P450 단백질은 약물 대사 및 콜레스테롤, 스테로이드 및 기타 지질의 합성에 관련된 많은 반응을 촉진하는 단옥시겐이다.이 단백질은 소포체 망막까지 국소화된다; 그것의 기질은 아직 결정되지 않았다.이 유전자는 두 개의 대본 변형을 생성하는 것으로, 19q 염색체에 있는 CYP2A, CYP2B, CYP2F 하위가족에서 나온 사이토크롬 P450 유전자의 큰 군집의 일부분이다.[7]
Wang HH, Liao YW, Chiang HL, et al. (2009). "Novel DNA sequence variations of cytochrome P450 genes in the Han Chinese population". Pharmacogenomics. 10 (3): 359–74. doi:10.2217/14622416.10.3.359. PMID19290787.
Fernandez-Salguero P, Gonzalez FJ (1995). "The CYP2A gene subfamily: species differences, regulation, catalytic activities and role in chemical carcinogenesis". Pharmacogenetics. 5 (Special Issue): S123–8. doi:10.1097/00008571-199512001-00013. PMID7581481.
Cauffiez C, Lo-Guidice JM, Quaranta S, et al. (2004). "Genetic polymorphism of the human cytochrome CYP2A13 in a French population: implication in lung cancer susceptibility". Biochem. Biophys. Res. Commun. 317 (2): 662–9. doi:10.1016/j.bbrc.2004.03.092. PMID15063809.
Smith G, Stubbins MJ, Harries LW, Wolf CR (1998). "Molecular genetics of the human cytochrome P450 monooxygenase superfamily". Xenobiotica. 28 (12): 1129–65. doi:10.1080/004982598238868. PMID9890157.
He XY, Shen J, Ding X, et al. (2004). "Identification of critical amino acid residues of human CYP2A13 for the metabolic activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a tobacco-specific carcinogen". Drug Metab. Dispos. 32 (12): 1516–21. doi:10.1124/dmd.104.001370. PMID15333516. S2CID26225467.
Nelson DR, Zeldin DC, Hoffman SM, et al. (2004). "Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants". Pharmacogenetics. 14 (1): 1–18. doi:10.1097/00008571-200401000-00001. PMID15128046.
He XY, Shen J, Hu WY, et al. (2004). "Identification of Val117 and Arg372 as critical amino acid residues for the activity difference between human CYP2A6 and CYP2A13 in coumarin 7-hydroxylation". Arch. Biochem. Biophys. 427 (2): 143–53. doi:10.1016/j.abb.2004.03.016. PMID15196988.
Herr D, Bettendorf H, Denschlag D, et al. (2006). "Cytochrome P2A13 and P1A1 gene polymorphisms are associated with the occurrence of uterine leiomyoma". Arch. Gynecol. Obstet. 274 (6): 367–71. doi:10.1007/s00404-006-0201-8. PMID16835796. S2CID28342598.
Song DK, Xing DL, Zhang LR, et al. (2009). "Association of NAT2, GSTM1, GSTT1, CYP2A6, and CYP2A13 gene polymorphisms with susceptibility and clinicopathologic characteristics of bladder cancer in Central China". Cancer Detect. Prev. 32 (5–6): 416–23. doi:10.1016/j.cdp.2009.02.003. PMID19303722.
Fujieda M, Yamazaki H, Kiyotani K, et al. (2003). "Eighteen novel polymorphisms of the CYP2A13 gene in Japanese". Drug Metab. Pharmacokinet. 18 (1): 86–90. doi:10.2133/dmpk.18.86. PMID15618722.
Wang H, Tan W, Hao B, et al. (2003). "Substantial reduction in risk of lung adenocarcinoma associated with genetic polymorphism in CYP2A13, the most active cytochrome P450 for the metabolic activation of tobacco-specific carcinogen NNK". Cancer Res. 63 (22): 8057–61. PMID14633739.
Cheng XY, Chen GL, Zhang WX, et al. (2004). "Arg257Cys polymorphism of CYP2A13 in a Chinese population". Clin. Chim. Acta. 343 (1–2): 213–6. doi:10.1016/j.cccn.2004.01.017. PMID15115698.
Cauffiez C, Pottier N, Tournel G, et al. (2005). "CYP2A13 genetic polymorphism in French Caucasian, Gabonese and Tunisian populations". Xenobiotica. 35 (7): 661–9. doi:10.1080/00498250500202171. PMID16316926. S2CID39901230.
Mohelnikova-Duchonova B, Vrana D, Holcatova I, et al. (2010). "CYP2A13, ADH1B, and ADH1C gene polymorphisms and pancreatic cancer risk". Pancreas. 39 (2): 144–8. doi:10.1097/MPA.0b013e3181bab6c2. PMID19812523. S2CID25113289.