FGF7
FGF7| FGF7 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| 에일리어스 | FGF7, HBGF-7, KGF, 섬유아세포증식인자 7 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| 외부 ID | OMIM: 148180 MGI: 95521 HomoloGene: 7316 GeneCard: FGF7 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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케라티노사이트 증식인자는 FGF7 [5][6][7]유전자에 의해 인간에게 암호화되는 단백질이다.
기능.
이 유전자에 의해 암호화된 단백질은 섬유아세포 성장인자(FGF) 계열의 구성원이다.FGF 패밀리는 광범위한 유사분열 및 세포 생존 활동을 가지고 있으며 배아 발달, 세포 성장, 형태 형성, 조직 복구, 종양 성장 및 침입을 포함한 다양한 생물학적 과정에 관여합니다.이 단백질은 강력한 상피 세포 특이적 성장 인자로, 그 승모원 활성은 주로 각질 세포에 나타나지만 섬유아세포와 내피 세포에는 나타나지 않는다.이 유전자의 생쥐와 쥐의 호몰로지에 대한 연구는 상피의 형태 형성, 상처의 재상피화, 모발 발달 및 초기 폐 조직 [7]형성에 대한 역할을 포함시켰다.
상호 작용
FGF7은 Perlecan과 [8]상호작용하는 것으로 나타났다.
레퍼런스
- ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000140285 - 앙상블, 2017년 5월
- ^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000027208 - 앙상블, 2017년 5월
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Mattei MG, deLapeyrière O, Bresnick J, Dickson C, Birnbaum D, Mason I (Mar 1995). "Mouse Fgf7 (fibroblast growth factor 7) and Fgf8 (fibroblast growth factor 8) genes map to chromosomes 2 and 19 respectively". Mammalian Genome. 6 (3): 196–7. doi:10.1007/BF00293012. PMID 7749227. S2CID 35553603.
- ^ Kelley MJ, Pech M, Seuanez HN, Rubin JS, O'Brien SJ, Aaronson SA (Oct 1992). "Emergence of the keratinocyte growth factor multigene family during the great ape radiation". Proceedings of the National Academy of Sciences of the United States of America. 89 (19): 9287–91. Bibcode:1992PNAS...89.9287K. doi:10.1073/pnas.89.19.9287. PMC 50111. PMID 1409637.
- ^ a b "Entrez Gene: FGF7 fibroblast growth factor 7 (keratinocyte growth factor)".
- ^ Mongiat M, Taylor K, Otto J, Aho S, Uitto J, Whitelock JM, Iozzo RV (Mar 2000). "The protein core of the proteoglycan perlecan binds specifically to fibroblast growth factor-7". The Journal of Biological Chemistry. 275 (10): 7095–100. doi:10.1074/jbc.275.10.7095. PMID 10702276.
추가 정보
- Beer HD, Gassmann MG, Munz B, Steiling H, Engelhardt F, Bleuel K, Werner S (Dec 2000). "Expression and function of keratinocyte growth factor and activin in skin morphogenesis and cutaneous wound repair". The Journal of Investigative Dermatology. Symposium Proceedings. 5 (1): 34–9. doi:10.1046/j.1087-0024.2000.00009.x. PMID 11147673.
- Ware LB, Matthay MA (May 2002). "Keratinocyte and hepatocyte growth factors in the lung: roles in lung development, inflammation, and repair". American Journal of Physiology. Lung Cellular and Molecular Physiology. 282 (5): L924–40. doi:10.1152/ajplung.00439.2001. PMID 11943656.
- Finch PW, Rubin JS (2004). Keratinocyte growth factor/fibroblast growth factor 7, a homeostatic factor with therapeutic potential for epithelial protection and repair. Advances in Cancer Research. Vol. 91. pp. 69–136. doi:10.1016/S0065-230X(04)91003-2. ISBN 978-0-12-006691-9. PMID 15327889.
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- Aaronson SA, Bottaro DP, Miki T, Ron D, Finch PW, Fleming TP, Ahn J, Taylor WG, Rubin JS (1992). "Keratinocyte growth factor. A fibroblast growth factor family member with unusual target cell specificity". Annals of the New York Academy of Sciences. 638: 62–77. doi:10.1111/j.1749-6632.1991.tb49018.x. PMID 1664700. S2CID 32054089.
- Finch PW, Rubin JS, Miki T, Ron D, Aaronson SA (Aug 1989). "Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth". Science. 245 (4919): 752–5. Bibcode:1989Sci...245..752F. doi:10.1126/science.2475908. PMID 2475908.
- Rubin JS, Osada H, Finch PW, Taylor WG, Rudikoff S, Aaronson SA (Feb 1989). "Purification and characterization of a newly identified growth factor specific for epithelial cells". Proceedings of the National Academy of Sciences of the United States of America. 86 (3): 802–6. Bibcode:1989PNAS...86..802R. doi:10.1073/pnas.86.3.802. PMC 286565. PMID 2915979.
- Ron D, Reich R, Chedid M, Lengel C, Cohen OE, Chan AM, Neufeld G, Miki T, Tronick SR (Mar 1993). "Fibroblast growth factor receptor 4 is a high affinity receptor for both acidic and basic fibroblast growth factor but not for keratinocyte growth factor". The Journal of Biological Chemistry. 268 (8): 5388–94. doi:10.1016/S0021-9258(18)53334-2. PMID 7680645.
- Yan G, Fukabori Y, McBride G, Nikolaropolous S, McKeehan WL (Aug 1993). "Exon switching and activation of stromal and embryonic fibroblast growth factor (FGF)-FGF receptor genes in prostate epithelial cells accompany stromal independence and malignancy". Molecular and Cellular Biology. 13 (8): 4513–22. doi:10.1128/MCB.13.8.4513. PMC 360063. PMID 7687739.
- Werner S, Smola H, Liao X, Longaker MT, Krieg T, Hofschneider PH, Williams LT (Nov 1994). "The function of KGF in morphogenesis of epithelium and reepithelialization of wounds". Science. 266 (5186): 819–22. Bibcode:1994Sci...266..819W. doi:10.1126/science.7973639. PMID 7973639.
- Wilson SE, Walker JW, Chwang EL, He YG (Jul 1993). "Hepatocyte growth factor, keratinocyte growth factor, their receptors, fibroblast growth factor receptor-2, and the cells of the cornea". Investigative Ophthalmology & Visual Science. 34 (8): 2544–61. PMID 8392040.
- Guo L, Degenstein L, Fuchs E (Jan 1996). "Keratinocyte growth factor is required for hair development but not for wound healing". Genes & Development. 10 (2): 165–75. doi:10.1101/gad.10.2.165. PMID 8566750.
- Ornitz DM, Xu J, Colvin JS, McEwen DG, MacArthur CA, Coulier F, Gao G, Goldfarb M (Jun 1996). "Receptor specificity of the fibroblast growth factor family". The Journal of Biological Chemistry. 271 (25): 15292–7. doi:10.1074/jbc.271.25.15292. PMID 8663044.
- Post M, Souza P, Liu J, Tseu I, Wang J, Kuliszewski M, Tanswell AK (Oct 1996). "Keratinocyte growth factor and its receptor are involved in regulating early lung branching". Development. 122 (10): 3107–15. doi:10.1242/dev.122.10.3107. PMID 8898224.
- Zimonjic DB, Kelley MJ, Rubin JS, Aaronson SA, Popescu NC (Oct 1997). "Fluorescence in situ hybridization analysis of keratinocyte growth factor gene amplification and dispersion in evolution of great apes and humans". Proceedings of the National Academy of Sciences of the United States of America. 94 (21): 11461–5. Bibcode:1997PNAS...9411461Z. doi:10.1073/pnas.94.21.11461. PMC 23506. PMID 9326632.
- Winkles JA, Alberts GF, Chedid M, Taylor WG, DeMartino S, Rubin JS (Dec 1997). "Differential expression of the keratinocyte growth factor (KGF) and KGF receptor genes in human vascular smooth muscle cells and arteries". Journal of Cellular Physiology. 173 (3): 380–6. doi:10.1002/(SICI)1097-4652(199712)173:3<380::AID-JCP10>3.0.CO;2-G. PMID 9369951.
- Ishibashi T, Tanaka T, Nibu K, Ishimoto S, Kaga K (Oct 1998). "Keratinocyte growth factor and its receptor messenger RNA expression in nasal mucosa and nasal polyps". The Annals of Otology, Rhinology, and Laryngology. 107 (10 Pt 1): 885–90. doi:10.1177/000348949810701013. PMID 9794620. S2CID 26406331.
- Mongiat M, Taylor K, Otto J, Aho S, Uitto J, Whitelock JM, Iozzo RV (Mar 2000). "The protein core of the proteoglycan perlecan binds specifically to fibroblast growth factor-7". The Journal of Biological Chemistry. 275 (10): 7095–100. doi:10.1074/jbc.275.10.7095. PMID 10702276.
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