IGFBP4
IGFBP4| IGFBP4 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| 에일리어스 | IGFBP4, BP-4, HT29-IGFBP, IBP4, IGFBP-4, 인슐린양성장인자결합단백질4 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| 외부 ID | OMIM: 146733 MGI: 96439 HomoloGene: 1192 GenCard: IGFBP4 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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인슐린양성장인자결합단백질4는 IGFBP4유전자에 [5][6][7]의해 인체 내에서 부호화되는 단백질이다.
기능.
이 유전자는 인슐린 유사성장인자결합단백질(IGFBP) 계열의 일원으로 IGFBP 도메인과 티로글로불린 Type-I 도메인을 가진 단백질을 암호화한다.단백질은 인슐린 유사 성장인자(IGF) I과 II를 모두 결합하고 글리코실화 및 비글리코실화 형태로 혈장 내에서 순환합니다.이 단백질의 결합은 IGF의 반감기를 연장하고 세포 표면 [8]수용체와의 상호작용을 변화시킨다.IGFBP-4는 독특한 단백질로 체내 및 체외에서 여러 암세포를 지속적으로 억제한다.그 억제 작용은 전립선과 대장에서 생체 내에서 나타났다.그것은 모든 대장암 세포에서 분비된다.
임상적 의의
단백질 자체가 [9]암의 형성을 막는 것은 아니다.그러나 그것은 암의 성장을 감소시키고 아포토시스 인자로 작용할 수 있다.
상호 작용
IGFBP4는 인슐린 유사 성장인자 1과 [10][11]2와 상호작용하는 것으로 나타났다.
레퍼런스
- ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000141753 - 앙상블, 2017년 5월
- ^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000017493 - 앙상블, 2017년 5월
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ LaTour D, Mohan S, Linkhart TA, Baylink DJ, Strong DD (May 1991). "Inhibitory insulin-like growth factor-binding protein: cloning, complete sequence, and physiological regulation". Mol Endocrinol. 4 (12): 1806–14. doi:10.1210/mend-4-12-1806. PMID 1707125.
- ^ Shimasaki S, Uchiyama F, Shimonaka M, Ling N (Mar 1991). "Molecular cloning of the cDNAs encoding a novel insulin-like growth factor-binding protein from rat and human". Mol Endocrinol. 4 (10): 1451–8. doi:10.1210/mend-4-10-1451. PMID 1704481.
- ^ Zazzi H, Nikoshkov A, Hall K, Luthman H (1998). "Structure and transcription regulation of the human insulin-like growth factor binding protein 4 gene (IGFBP4)". Genomics. 49 (3): 401–10. doi:10.1006/geno.1998.5283. PMID 9615225.
- ^ "Entrez Gene: IGFBP4 insulin-like growth factor binding protein 4".
- ^ Durai R, Yang SY, Seifalian AM, Goldspink G, Winslet MC (2007). "Role of insulin-like growth factor binding protein-4 in prevention of colon cancer". World J Surg Oncol. 5: 128. doi:10.1186/1477-7819-5-128. PMC 2203999. PMID 17988381.
- ^ Bach LA, Hsieh S, Sakano K, Fujiwara H, Perdue JF, Rechler MM (May 1993). "Binding of mutants of human insulin-like growth factor II to insulin-like growth factor binding proteins 1-6". J. Biol. Chem. 268 (13): 9246–54. doi:10.1016/S0021-9258(18)98342-0. PMID 7683646.
- ^ Qin X, Strong DD, Baylink DJ, Mohan S (Sep 1998). "Structure-function analysis of the human insulin-like growth factor binding protein-4". J. Biol. Chem. 273 (36): 23509–16. doi:10.1074/jbc.273.36.23509. PMID 9722589.
추가 정보
- Rajaram S, Baylink DJ, Mohan S (1998). "Insulin-like growth factor-binding proteins in serum and other biological fluids: regulation and functions". Endocr. Rev. 18 (6): 801–31. doi:10.1210/edrv.18.6.0321. PMID 9408744.
- Zhou R, Diehl D, Hoeflich A, Lahm H, Wolf E (2003). "IGF-binding protein-4: biochemical characteristics and functional consequences". J. Endocrinol. 178 (2): 177–93. doi:10.1677/joe.0.1780177. PMID 12904166.
- Durai R, Davies M, Yang W, Yang SY, Seifalian A, Goldspink G, Winslet M (2006). "Biology of insulin-like growth factor binding protein-4 and its role in cancer (review)". Int. J. Oncol. 28 (6): 1317–25. doi:10.3892/ijo.28.6.1317. PMID 16685432.
- Giudice LC, Dsupin BA, Irwin JC, Eckert RL (1992). "Identification of insulin-like growth factor binding proteins in human oviduct". Fertil. Steril. 57 (2): 294–301. doi:10.1016/S0015-0282(16)54833-X. PMID 1370941.
- Bajalica S, Allander SV, Ehrenborg E, Brøndum-Nielsen K, Luthman H, Larsson C (1992). "Localization of the human insulin-like growth-factor-binding protein 4 gene to chromosomal region 17q12-21.1". Hum. Genet. 89 (2): 234–6. doi:10.1007/BF00217129. PMID 1375185. S2CID 22341448.
- Kiefer MC, Schmid C, Waldvogel M, Schläpfer I, Futo E, Masiarz FR, Green K, Barr PJ, Zapf J (1992). "Characterization of recombinant human insulin-like growth factor binding proteins 4, 5, and 6 produced in yeast". J. Biol. Chem. 267 (18): 12692–9. doi:10.1016/S0021-9258(18)42332-0. PMID 1377672.
- Zhou J, Bondy C (1992). "Insulin-like growth factor-II and its binding proteins in placental development". Endocrinology. 131 (3): 1230–40. doi:10.1210/en.131.3.1230. PMID 1380437.
- Kiefer MC, Masiarz FR, Bauer DM, Zapf J (1991). "Identification and molecular cloning of two new 30-kDa insulin-like growth factor binding proteins isolated from adult human serum". J. Biol. Chem. 266 (14): 9043–9. doi:10.1016/S0021-9258(18)31549-7. PMID 1709161.
- Culouscou JM, Shoyab M (1991). "Purification of a colon cancer cell growth inhibitor and its identification as an insulin-like growth factor binding protein". Cancer Res. 51 (11): 2813–9. PMID 1709585.
- Tonin P, Ehrenborg E, Lenoir G, Feunteun J, Lynch H, Morgan K, Zazzi H, Vivier A, Pollak M, Huynh H (1994). "The human insulin-like growth factor-binding protein 4 gene maps to chromosome region 17q12-q21.1 and is close to the gene for hereditary breast-ovarian cancer". Genomics. 18 (2): 414–7. doi:10.1006/geno.1993.1487. PMID 7507078.
- Ilvesmäki V, Blum WF, Voutilainen R (1994). "Insulin-like growth factor binding proteins in the human adrenal gland". Mol. Cell. Endocrinol. 97 (1–2): 71–9. doi:10.1016/0303-7207(93)90212-3. PMID 7511544. S2CID 22503525.
- Zhou J, Bondy C (1993). "Anatomy of the human ovarian insulin-like growth factor system". Biol. Reprod. 48 (3): 467–82. doi:10.1095/biolreprod48.3.467. PMID 7680905.
- Conover CA, Clarkson JT, Bale LK (1993). "Phorbol ester tumor promoters regulate insulin-like growth factor-binding protein-4 proteolysis". Endocrinology. 133 (3): 1347–51. doi:10.1210/endo.133.3.7689953. PMID 7689953.
- Fridell RA, Harding LS, Bogerd HP, Cullen BR (1995). "Identification of a novel human zinc finger protein that specifically interacts with the activation domain of lentiviral Tat proteins". Virology. 209 (2): 347–57. doi:10.1006/viro.1995.1266. PMID 7778269.
- Batch JA, Mercuri FA, Werther GA (1996). "Identification and localization of insulin-like growth factor-binding protein (IGFBP) messenger RNAs in human hair follicle dermal papilla". J. Invest. Dermatol. 106 (3): 471–5. doi:10.1111/1523-1747.ep12343649. PMID 8648179.
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Han VK, Matsell DG, Delhanty PJ, Hill DJ, Shimasaki S, Nygard K (1996). "IGF-binding protein mRNAs in the human fetus: tissue and cellular distribution of developmental expression". Horm. Res. 45 (3–5): 160–6. doi:10.1159/000184780. PMID 8964576.
- Di Battista JA, Doré S, Morin N, He Y, Pelletier JP, Martel-Pelletier J (1997). "Prostaglandin E2 stimulates insulin-like growth factor binding protein-4 expression and synthesis in cultured human articular chondrocytes: possible mediation by Ca(++)-calmodulin regulated processes". J. Cell. Biochem. 65 (3): 408–19. doi:10.1002/(SICI)1097-4644(19970601)65:3<408::AID-JCB10>3.0.CO;2-B. PMID 9138096.
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