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Advancing Julia

Repos that advance Julia as a compelling scientific programming language.
53 repositories

AI-Assisted Engineering

Programming will never be the same.
13 repositories

Bioinformatics

"Bioinformatics is terrible. Everybody knows bioinformatics is terrible...it’s not a good situation that we’re in."
159 repositories

Biology in the Frontend

Interactive simulations, visualizations, and demos served in the browser.
30 repositories

Command-line Utilities

Future-facing command-line tools written in innovative languages or that raise the bar in some other way.
137 repositories

Data Visualization

Know your data by seeing it.
82 repositories

Design as Code

3 repositories

Functional Programming

Writing composable, refactorable, and robust code with an FP paradigm
62 repositories

Genomic epidemiology🦠🧬

7 repositories

Get started in Bioinformatics

Looking for inspiration to get started with making sense of noisy biological data? These repos punch above their weight.
14 repositories

GIS

Spatial statistics, cartography, and other spatially explicit methods
3 repositories

Gleam is cool

27 repositories

Glimpses of Jai

Early looks at the Jai programming language, which remains in closed beta
1 repository

Go in Bioinformatics

Tools built in Go that can be interfaced with in the command line, or in Go source code.
28 repositories

i use neovim, btw

we don't talk about vscode in this household
9 repositories

Learning Me a Haskell

Finally giving in and learning Haskell—I may never be the same
2 repositories

Metagenomics is hard :(

but fun?
26 repositories

Python as a Glue Language

Python is beautiful...but slow. These tools help bring out its best side: as an elegant glue language connecting faster pieces of software.
158 repositories

R in Science

"The best thing about R is it was designed by statisticians. The worst thing about R is it was designed by statisticians."
43 repositories

Reading

Open-source books and docs distributed on GitHub
2 repositories

Rust in Bioinformatics (and Beyond!)

Tools built in Rust that can be interfaced with in the command line, or in Rust source code.
568 repositories

Scientific Reproducibility

Tools that make doing reproducible science—a very difficult task!—easier.
16 repositories

Simulation & Testing

25 repositories

Software for Biodiversity

Software developed to help understand and solve the biodiversity crisis and advance our understanding of ecology and evolution in general.
43 repositories

Standards for Excellent Programs

23 repositories

TUIs

I love TUIs and I don't care who knows it
59 repositories

Turns out your app is a database

Repos that are explicitly--or accidentally--database projects.
39 repositories

TypeScript Eats the World

We all give into TypeScript eventually...
72 repositories

Workflow Orchestration

Tools for deploying many steps of dataflow across a variety of infrastructures
11 repositories
83 stars written in C++
Clear filter

Truly independent web browser

C++ 62,072 2,915 Updated Apr 4, 2026

aria2 is a lightweight multi-protocol & multi-source, cross platform download utility operated in command-line. It supports HTTP/HTTPS, FTP, SFTP, BitTorrent and Metalink.

C++ 40,473 3,833 Updated Mar 10, 2026

A library for efficient similarity search and clustering of dense vectors.

C++ 39,599 4,313 Updated Apr 3, 2026

Parsing gigabytes of JSON per second : used by Facebook/Meta Velox, the Node.js runtime, ClickHouse, WatermelonDB, Apache Doris, Milvus, StarRocks

C++ 23,587 1,232 Updated Apr 3, 2026

Nix, the purely functional package manager

C++ 16,492 1,877 Updated Apr 4, 2026

A focused launcher for your desktop — native, fast, extensible

C++ 7,057 176 Updated Apr 4, 2026

lightweight, standalone C++ inference engine for Google's Gemma models.

C++ 6,778 607 Updated Apr 2, 2026

Functional programming language for signal processing and sound synthesis

C++ 3,004 404 Updated Mar 30, 2026

Compiler for multiple programming models (SYCL, C++ standard parallelism, HIP/CUDA) for CPUs and GPUs from all vendors: The independent, community-driven compiler for C++-based heterogeneous progra…

C++ 1,817 212 Updated Apr 2, 2026

Bayesian haplotype-based genetic polymorphism discovery and genotyping.

C++ 864 275 Updated Feb 8, 2026

LadybugDB a graph database

C++ 856 63 Updated Apr 3, 2026

Oxford Nanopore's Basecaller

C++ 811 116 Updated Feb 19, 2026

Python and C++ code for reading and writing genomics data.

C++ 798 120 Updated Dec 9, 2021

Versatile open-source tool for microbiome analysis

C++ 741 134 Updated Mar 27, 2026

Ultra-fast and memory-efficient (meta-)genome assembler

C++ 702 140 Updated Oct 28, 2025

a Bioinformatics Application for Navigating De novo Assembly Graphs Easily

C++ 669 113 Updated Dec 3, 2022

Next-Gen Big Data File Format

C++ 667 36 Updated Apr 3, 2026

simple and scalable statistical modelling in R

C++ 598 66 Updated Feb 8, 2026

quality filtering tool for long reads

C++ 397 30 Updated Sep 17, 2025

Genome browser and variant annotation

C++ 392 10 Updated Oct 30, 2025

PRQL as a DuckDB extension

C++ 318 9 Updated Sep 22, 2025

Lower-latency OpenMP-style minimalistic scoped thread-pool designed for 'Fork-Join' parallelism in Rust and C++, avoiding memory allocations, mutexes, CAS-primitives, and false-sharing on the hot p…

C++ 317 23 Updated Apr 2, 2026

Ultrafast consensus module for raw de novo genome assembly of long uncorrected reads. http://genome.cshlp.org/content/early/2017/01/18/gr.214270.116 Note: This was the original repository which wil…

C++ 297 53 Updated May 9, 2024

Classifier for metagenomic sequences

C++ 272 75 Updated Jun 20, 2025

classify, merge, tracking and annotation of GFF files by comparing to a reference annotation GFF

C++ 268 34 Updated Mar 15, 2026

Program for analysing NGS data.

C++ 257 58 Updated Mar 6, 2025

🐙 KrakenUniq: Metagenomics classifier with unique k-mer counting for more specific results

C++ 244 42 Updated Jan 18, 2024

Accurate Species Tree EstimatoR: a family of optimation algorithms for species tree inference (including ASTRAL & CASTER)

C++ 234 19 Updated Mar 27, 2026

De novo genome assembler for long uncorrected reads

C++ 231 19 Updated Nov 15, 2023

Ultra-fast preprocessing and quality control for long-read sequencing data

C++ 226 15 Updated Sep 6, 2025
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