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Advancing Julia

Repos that advance Julia as a compelling scientific programming language.
53 repositories

AI-Assisted Engineering

Programming will never be the same.
13 repositories

Bioinformatics

"Bioinformatics is terrible. Everybody knows bioinformatics is terrible...it’s not a good situation that we’re in."
159 repositories

Biology in the Frontend

Interactive simulations, visualizations, and demos served in the browser.
30 repositories

Command-line Utilities

Future-facing command-line tools written in innovative languages or that raise the bar in some other way.
137 repositories

Data Visualization

Know your data by seeing it.
82 repositories

Design as Code

3 repositories

Functional Programming

Writing composable, refactorable, and robust code with an FP paradigm
62 repositories

Genomic epidemiology🦠🧬

7 repositories

Get started in Bioinformatics

Looking for inspiration to get started with making sense of noisy biological data? These repos punch above their weight.
14 repositories

GIS

Spatial statistics, cartography, and other spatially explicit methods
3 repositories

Gleam is cool

27 repositories

Glimpses of Jai

Early looks at the Jai programming language, which remains in closed beta
1 repository

Go in Bioinformatics

Tools built in Go that can be interfaced with in the command line, or in Go source code.
28 repositories

i use neovim, btw

we don't talk about vscode in this household
9 repositories

Learning Me a Haskell

Finally giving in and learning Haskell—I may never be the same
2 repositories

Metagenomics is hard :(

but fun?
26 repositories

Python as a Glue Language

Python is beautiful...but slow. These tools help bring out its best side: as an elegant glue language connecting faster pieces of software.
158 repositories

R in Science

"The best thing about R is it was designed by statisticians. The worst thing about R is it was designed by statisticians."
43 repositories

Reading

Open-source books and docs distributed on GitHub
2 repositories

Rust in Bioinformatics (and Beyond!)

Tools built in Rust that can be interfaced with in the command line, or in Rust source code.
569 repositories

Scientific Reproducibility

Tools that make doing reproducible science—a very difficult task!—easier.
16 repositories

Simulation & Testing

25 repositories

Software for Biodiversity

Software developed to help understand and solve the biodiversity crisis and advance our understanding of ecology and evolution in general.
43 repositories

Standards for Excellent Programs

23 repositories

TUIs

I love TUIs and I don't care who knows it
59 repositories

Turns out your app is a database

Repos that are explicitly--or accidentally--database projects.
39 repositories

TypeScript Eats the World

We all give into TypeScript eventually...
72 repositories

Workflow Orchestration

Tools for deploying many steps of dataflow across a variety of infrastructures
11 repositories
263 stars written in Python
Clear filter

Learn how to design large-scale systems. Prep for the system design interview. Includes Anki flashcards.

Python 341,347 55,199 Updated Mar 20, 2026

Python tool for converting files and office documents to Markdown.

Python 93,267 5,625 Updated Mar 30, 2026

Animation engine for explanatory math videos

Python 85,755 7,195 Updated Mar 26, 2026

A curated list of awesome Machine Learning frameworks, libraries and software.

Python 72,151 15,395 Updated Mar 15, 2026

The uncompromising Python code formatter

Python 41,440 2,745 Updated Mar 30, 2026

What the f*ck Python? 😱

Python 36,917 2,667 Updated Jan 13, 2026

Composable transformations of Python+NumPy programs: differentiate, vectorize, JIT to GPU/TPU, and more

Python 35,298 3,503 Updated Apr 4, 2026

Intelligent automation and multi-agent orchestration for Claude Code

Python 32,929 3,590 Updated Apr 3, 2026

⚡ A Fast, Extensible Progress Bar for Python and CLI

Python 31,083 1,442 Updated Feb 14, 2026

Data validation using Python type hints

Python 27,346 2,525 Updated Apr 3, 2026

A cross-platform command-line utility that creates projects from cookiecutters (project templates), e.g. Python package projects, C projects.

Python 24,794 2,218 Updated Apr 1, 2026

Python logging made (stupidly) simple

Python 23,774 780 Updated Apr 1, 2026

Turn (almost) any Python command line program into a full GUI application with one line

Python 22,014 1,043 Updated Mar 23, 2026

A reactive notebook for Python — run reproducible experiments, query with SQL, execute as a script, deploy as an app, and version with git. Stored as pure Python. All in a modern, AI-native editor.

Python 20,133 1,011 Updated Apr 3, 2026

Typer, build great CLIs. Easy to code. Based on Python type hints.

Python 19,147 868 Updated Apr 3, 2026

An extremely fast Python type checker and language server, written in Rust.

Python 18,179 276 Updated Apr 2, 2026

A set of ready to use Agent Skills for research, science, engineering, analysis, finance and writing.

Python 17,309 1,908 Updated Apr 3, 2026

A high-performance, zero-overhead, extensible Python compiler with built-in NumPy support

Python 16,699 599 Updated Apr 2, 2026

Resume builder for academics and engineers

Python 16,187 1,164 Updated Apr 1, 2026

🚀 Level up your GitHub profile readme with customizable cards including LOC statistics!

Python 16,076 117 Updated Jan 25, 2025

PyGWalker: Turn your dataframe into an interactive UI for visual analysis

Python 15,708 860 Updated Apr 4, 2026

An orchestration platform for the development, production, and observation of data assets.

Python 15,196 2,047 Updated Apr 3, 2026

Gel supercharges Postgres with a modern data model, graph queries, Auth & AI solutions, and much more.

Python 14,091 448 Updated Dec 24, 2025

Parallel computing with task scheduling

Python 13,780 1,860 Updated Apr 2, 2026

The pytest framework makes it easy to write small tests, yet scales to support complex functional testing

Python 13,728 3,075 Updated Apr 1, 2026

Access large language models from the command-line

Python 11,520 788 Updated Mar 31, 2026

NumPy & SciPy for GPU

Python 10,881 1,012 Updated Mar 29, 2026

Declarative visualization library for Python

Python 10,321 843 Updated Apr 3, 2026

🍦 Never use print() to debug again.

Python 10,032 217 Updated Apr 3, 2026

A modular SQL linter and auto-formatter with support for multiple dialects and templated code.

Python 9,617 971 Updated Apr 4, 2026
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