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307 stars written in Python
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Differential expression analysis for single-cell RNA-seq data.

Python 204 22 Updated Oct 21, 2025

让我们以刷LeetCode题目的形式,来编程解决生物信息学问题吧,Come on

Python 200 57 Updated Dec 3, 2022

TOGA (Tool to infer Orthologs from Genome Alignments): implements a novel paradigm to infer orthologous genes. TOGA integrates gene annotation, inferring orthologs and classifying genes as intact o…

Python 196 27 Updated Jun 18, 2025

“When everything is connected to everything else, for better or worse, everything matters.” Bruce Mau

Python 189 78 Updated Jul 13, 2020

SALSA: A tool to scaffold long read assemblies with Hi-C data

Python 187 48 Updated May 17, 2024

Earl Grey: A fully automated TE curation and annotation pipeline

Python 185 25 Updated Sep 16, 2025

RaGOO is no longer supported. Please use RagTag instead: https://github.com/malonge/RagTag

Python 172 28 Updated May 30, 2021

Modified version of Alphafold to divide CPU part (MSA and template searching) and GPU part. This can accelerate Alphafold when predicting multiple structures

Python 171 49 Updated Feb 25, 2024

Chromosome-level scaffolding using multiple references

Python 162 26 Updated Sep 8, 2024

snipit: summarise snps relative to your reference sequence

Python 162 30 Updated Sep 21, 2025

pbsv - PacBio structural variant (SV) calling and analysis tools

Python 160 26 Updated Feb 26, 2025

Tools for manipulating biological data, particularly multiple sequence alignments

Python 158 55 Updated Oct 28, 2025

WGDI: A user-friendly toolkit for evolutionary analyses of whole-genome duplications and ancestral karyotypes

Python 149 25 Updated Nov 4, 2025

FAN-C: Framework for the ANalysis of C-like data

Python 120 17 Updated Mar 13, 2024

Extract 3D contacts (.pairs) from sequencing alignments

Python 116 36 Updated Nov 3, 2025

An imagemagick-like frontend to Biopython SeqIO

Python 116 22 Updated Mar 18, 2024

Publication quality NGS track plotting

Python 114 20 Updated Oct 10, 2025

Detecting genome structural variants with deep learning in single molecule sequencing

Python 113 11 Updated Apr 9, 2025

TADbit is a complete Python library to deal with all steps to analyze, model and explore 3C-based data. With TADbit the user can map FASTQ files to obtain raw interaction binned matrices (Hi-C like…

Python 106 62 Updated Nov 6, 2025

Mikado is a lightweight Python3 pipeline whose purpose is to facilitate the identification of expressed loci from RNA-Seq data * and to select the best models in each locus.

Python 104 18 Updated Feb 7, 2025

My solution to Bioinformatics Specialization (Finding Hidden Messages in DNA; Genome Sequencing; Comparing Genes, Proteins, and Genomes; Molecular Evolution; Genomic Data Science and Clustering; Fi…

Python 97 45 Updated Nov 1, 2018

Neural network classification of TE

Python 96 6 Updated Oct 9, 2025

PASTA (Practical Alignment using SATe and Transitivity)

Python 94 28 Updated Jun 5, 2025

Fit-Hi-C is a tool for assigning statistical confidence estimates to chromosomal contact maps produced by genome-wide genome architecture assays such as Hi-C.

Python 91 19 Updated Aug 29, 2022

ATAC-seq snakemake pipeline

Python 88 30 Updated Feb 13, 2020

Distribution package for the Prgressive Cactus multiple genome aligner. Dependencies are linked as submodules

Python 88 26 Updated Jun 19, 2018

Calculate summary statistics and manipulate multiple sequence alignments

Python 87 15 Updated Feb 1, 2024

Python package and CLI for whole-genome duplication related analyses. **This package is deprecated in favor of** https://github.com/heche-psb/wgd.

Python 86 43 Updated Oct 11, 2023

software for UCE (and general) phylogenomics

Python 84 51 Updated Mar 19, 2025