CEBPE

CEBPE
사용 가능한 구조
PDB	Ortholog 검색: PDBe RCSB
PDB ID 코드 목록
	3T92
식별자
에일리어스	CEBPE, C/EBP-epsilon, CRP1, CCAAT/enhancer 결합단백질 엡실론, CCAAT 강화단백질 엡실론, c/EBP 엡실론
외부 ID	OMIM: 600749 MGI: 103572 HomoloGene: 1367 GeneCard: CEBPE
유전자 위치(인간)
크르.	14번 염색체(인간)
끝.	23,120,256 bp
유전자 위치(마우스)
크르.	14번 염색체(쥐)
끝.	54,949,631 bp
RNA발현패턴
	상단 표시 위치:
	골수; ; 결석골; ; 골수 세포; ; 피; ; 단구; ; 대정맥; ; 비장; ; 십이지장; ; 맹장; ; 근육 조직;
	상단 표시 위치:
	골수; ; 간; ; jejunum; ; 회장; ; 비장; ; 입술; ; 대퇴 사두근; ; 결장; ; 십이지장; ; 배;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	단백질 헤테로다이머화 활성; DNA결합전사인자활성; RNA중합효소II 시스조절영역배열특이적 DNA결합; DNA결합; DNA결합전사활성화제, RNA중합효소II 특이적; 단백질 호모다이머화; 단백질 결합; DNA결합전사인자활성, RNA중합효소II 특이적;
셀룰러 컴포넌트	핵소체; 핵;
생물학적 과정	방위 응답; 골수세포분화; 유전자 발현 양성 조절; 리포다당류에 대한 세포반응; 전사조절, DNA템플릿화; 세균에 대한 방어 반응; 전사, DNA 템플릿; RNA중합효소II에 의한 전사의 양성 조절; 대식세포 분화; 식세포증; RNA중합효소II에 의한 전사; 과립구 분화;
	출처:아미고 / QuickGO
맞춤법
	1053
	110794
	ENSG000092067
	ENSMUSG000052435
	문제 15744
	Q6PZD9
	NM_001805
	NM_207131
	NP_001796
	NP_997014
	위키데이터
인간 보기/편집	마우스 표시/편집

CEBPE 및 CRP1로도 알려진 CCAAT/증강제 결합 단백질(C/EBP)은 CCAat-증강제 결합 단백질의 일종이다.CEBPE는 인간의^[5]^[6] 유전자로 ^[7]아포토시스적이다.

이 유전자에 의해 암호화된 단백질은 특정 DNA 조절 영역에 호모디머로 결합할 수 있는 bZIP 전사 인자입니다.또한 관련 단백질 CEBP-γ와 함께 헤테로디미터를 형성할 수 있다.코드화된 단백질은 기탁 과립구 전구세포의 말단 분화와 기능적 성숙에 필수적일 수 있다.이 유전자의 돌연변이는 희귀한 선천성 질환인 특정 과립 결핍과 관련이 있다.이 유전자의 여러 변종이 설명되었지만, 오직 한 가지 유전자의 전체 길이 성질이 결정되었다.^[5]

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG000092067 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000052435 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon".
^ Antonson P, Stellan B, Yamanaka R, Xanthopoulos KG (Jul 1996). "A novel human CCAAT/enhancer binding protein gene, C/EBPepsilon, is expressed in cells of lymphoid and myeloid lineages and is localized on chromosome 14q11.2 close to the T-cell receptor alpha/delta locus". Genomics. 35 (1): 30–8. doi:10.1006/geno.1996.0319. PMID 8661101.
^ Nakajima H, Watanabe N, Shibata F, Kitamura T, Ikeda Y, Handa M (May 2006). "N-terminal region of CCAAT/enhancer-binding protein epsilon is critical for cell cycle arrest, apoptosis, and functional maturation during myeloid differentiation". The Journal of Biological Chemistry. 281 (20): 14494–502. doi:10.1074/jbc.M600575200. PMID 16531405.

추가 정보

Sladek FM, Darnell JE (Apr 1992). "Mechanisms of liver-specific gene expression". Current Opinion in Genetics & Development. 2 (2): 256–9. doi:10.1016/S0959-437X(05)80282-5. PMID 1638120.
Gombart AF, Koeffler HP (Jan 2002). "Neutrophil specific granule deficiency and mutations in the gene encoding transcription factor C/EBP(epsilon)". Current Opinion in Hematology. 9 (1): 36–42. doi:10.1097/00062752-200201000-00007. PMID 11753076. S2CID 25411864.
Williams SC, Cantwell CA, Johnson PF (Sep 1991). "A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro". Genes & Development. 5 (9): 1553–67. doi:10.1101/gad.5.9.1553. PMID 1884998.
Antonson P, Stellan B, Yamanaka R, Xanthopoulos KG (Jul 1996). "A novel human CCAAT/enhancer binding protein gene, C/EBPepsilon, is expressed in cells of lymphoid and myeloid lineages and is localized on chromosome 14q11.2 close to the T-cell receptor alpha/delta locus". Genomics. 35 (1): 30–8. doi:10.1006/geno.1996.0319. PMID 8661101.
Chumakov AM, Grillier I, Chumakova E, Chih D, Slater J, Koeffler HP (Mar 1997). "Cloning of the novel human myeloid-cell-specific C/EBP-epsilon transcription factor". Molecular and Cellular Biology. 17 (3): 1375–86. doi:10.1128/mcb.17.3.1375. PMC 231862. PMID 9032264.
Yamanaka R, Kim GD, Radomska HS, Lekstrom-Himes J, Smith LT, Antonson P, Tenen DG, Xanthopoulos KG (Jun 1997). "CCAAT/enhancer binding protein epsilon is preferentially up-regulated during granulocytic differentiation and its functional versatility is determined by alternative use of promoters and differential splicing". Proceedings of the National Academy of Sciences of the United States of America. 94 (12): 6462–7. doi:10.1073/pnas.94.12.6462. PMC 21072. PMID 9177240.
Verbeek W, Gombart AF, Chumakov AM, Müller C, Friedman AD, Koeffler HP (May 1999). "C/EBPepsilon directly interacts with the DNA binding domain of c-myb and cooperatively activates transcription of myeloid promoters". Blood. 93 (10): 3327–37. doi:10.1182/blood.V93.10.3327. PMID 10233885.
Lekstrom-Himes JA, Dorman SE, Kopar P, Holland SM, Gallin JI (Jun 1999). "Neutrophil-specific granule deficiency results from a novel mutation with loss of function of the transcription factor CCAAT/enhancer binding protein epsilon". The Journal of Experimental Medicine. 189 (11): 1847–52. doi:10.1084/jem.189.11.1847. PMC 2193089. PMID 10359588.
Tavor S, Vuong PT, Park DJ, Gombart AF, Cohen AH, Koeffler HP (Mar 2002). "Macrophage functional maturation and cytokine production are impaired in C/EBP epsilon-deficient mice". Blood. 99 (5): 1794–801. doi:10.1182/blood.V99.5.1794. PMID 11861297.
Zhang P, Nelson E, Radomska HS, Iwasaki-Arai J, Akashi K, Friedman AD, Tenen DG (Jun 2002). "Induction of granulocytic differentiation by 2 pathways". Blood. 99 (12): 4406–12. doi:10.1182/blood.V99.12.4406. PMID 12036869.
Kim J, Cantwell CA, Johnson PF, Pfarr CM, Williams SC (Oct 2002). "Transcriptional activity of CCAAT/enhancer-binding proteins is controlled by a conserved inhibitory domain that is a target for sumoylation". The Journal of Biological Chemistry. 277 (41): 38037–44. doi:10.1074/jbc.M207235200. PMID 12161447.
Du J, Stankiewicz MJ, Liu Y, Xi Q, Schmitz JE, Lekstrom-Himes JA, Ackerman SJ (Nov 2002). "Novel combinatorial interactions of GATA-1, PU.1, and C/EBPepsilon isoforms regulate transcription of the gene encoding eosinophil granule major basic protein". The Journal of Biological Chemistry. 277 (45): 43481–94. doi:10.1074/jbc.M204777200. PMID 12202480.
Truong BT, Lee YJ, Lodie TA, Park DJ, Perrotti D, Watanabe N, Koeffler HP, Nakajima H, Tenen DG, Kogan SC (Feb 2003). "CCAAT/Enhancer binding proteins repress the leukemic phenotype of acute myeloid leukemia". Blood. 101 (3): 1141–8. doi:10.1182/blood-2002-05-1374. PMID 12393450.
Gombart AF, Kwok SH, Anderson KL, Yamaguchi Y, Torbett BE, Koeffler HP (Apr 2003). "Regulation of neutrophil and eosinophil secondary granule gene expression by transcription factors C/EBP epsilon and PU.1". Blood. 101 (8): 3265–73. doi:10.1182/blood-2002-04-1039. PMID 12515729.
Khanna-Gupta A, Zibello T, Sun H, Gaines P, Berliner N (May 2003). "Chromatin immunoprecipitation (ChIP) studies indicate a role for CCAAT enhancer binding proteins alpha and epsilon (C/EBP alpha and C/EBP epsilon ) and CDP/cut in myeloid maturation-induced lactoferrin gene expression". Blood. 101 (9): 3460–8. doi:10.1182/blood-2002-09-2767. PMID 12522000.
Gery S, Gombart AF, Fung YK, Koeffler HP (Feb 2004). "C/EBPepsilon interacts with retinoblastoma and E2F1 during granulopoiesis". Blood. 103 (3): 828–35. doi:10.1182/blood-2003-01-0159. PMID 12947005.
Gery S, Park DJ, Vuong PT, Chih DY, Lemp N, Koeffler HP (Dec 2004). "Retinoic acid regulates C/EBP homologous protein expression (CHOP), which negatively regulates myeloid target genes". Blood. 104 (13): 3911–7. doi:10.1182/blood-2003-10-3688. PMID 15308577.

외부 링크

CEBPE 단백질, 미국 국립 의학 도서관(MeSH)의 인간
UCSC Genome Browser의 인간 CEBPE 게놈 위치 및 CEBPE 유전자 상세 페이지.

이 기사에는 미국 국립 의학 도서관(미국 국립 의학 도서관)의 공공 도메인 텍스트가 포함되어 있습니다.

인간 염색체 14번 유전자에 대한 이 기사는 짧은 글이다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG000092067 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000052435 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon".

[pmid8661101-6] Antonson P, Stellan B, Yamanaka R, Xanthopoulos KG (Jul 1996). "A novel human CCAAT/enhancer binding protein gene, C/EBPepsilon, is expressed in cells of lymphoid and myeloid lineages and is localized on chromosome 14q11.2 close to the T-cell receptor alpha/delta locus". Genomics. 35 (1): 30–8. doi:10.1006/geno.1996.0319. PMID 8661101.

[pmid16531405-7] Nakajima H, Watanabe N, Shibata F, Kitamura T, Ikeda Y, Handa M (May 2006). "N-terminal region of CCAAT/enhancer-binding protein epsilon is critical for cell cycle arrest, apoptosis, and functional maturation during myeloid differentiation". The Journal of Biological Chemistry. 281 (20): 14494–502. doi:10.1074/jbc.M600575200. PMID 16531405.

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CEBPE

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레퍼런스

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