TLX1

TLX1
식별자
에일리어스	TLX1, HOX11, TCL3, T세포 백혈병 호메오박스1, T세포 백혈병 호메오박스1
외부 ID	OMIM : 186770 MGI : 98769 HomoloGene : 4031 GeneCard : TLX1
유전자 위치(인간)
크르.	10번 염색체(인간)
끝.	101,137,789 bp
유전자 위치(마우스)
크르.	19번 염색체(쥐)
끝.	45,182,382 bp
RNA발현패턴
	상단 표시 위치:
	비장; ; 소침샘; ; 간우엽; ; 십이지장; ; 흉선; ; 심실; ; 좌심실; ; 아트리움; ; 우심방; ; 직장;
	상단 표시 위치:
	배장간막; ; 혀; ; 중이; ; 턱밑샘; ; 외이; ; 귓바퀴; ; 암요도; ; 남성 요도; ; 이관; ; 비장;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	RNA중합효소II 시스조절영역배열특이적 DNA결합; DNA결합; 배열특이적 DNA결합; DNA결합전사활성화제, RNA중합효소II 특이적; 단백질 결합; DNA결합전사인자활성, RNA중합효소II 특이적; DNA결합전사인자활성;
셀룰러 컴포넌트	핵;
생물학적 과정	다세포 생물 발달; 전사조절, DNA템플릿화; RNA중합효소II에 의한 전사; RNA중합효소II에 의한 전사의 양성 조절; RNA중합효소II에 의한 전사조절;
	출처:아미고 / QuickGO
맞춤법
	3195
	21908
	ENSG00000107807
	ENSMUSG000025215
	P31314
	P43345
	NM_001195517; NM_005521
	NM_021901
	NP_001182446; NP_005512
	없음
	위키데이터
인간 보기/편집	마우스 표시/편집

T세포 백혈병 호메오박스 단백질 1은 처음에 HOX11이라고 이름 붙여진 TLX1 ^[5]^[6]^[7]^[8]^[9]유전자에 의해 인체에서 암호화되는 단백질이다.

상호 작용

TLX1은 PPP1CC,^[10] PPP2CB^[10] 및 PPP2CA와 ^[10]대화하는 것으로 나타났습니다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000107807 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000025215 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hatano M, Roberts CW, Minden M, Crist WM, Korsmeyer SJ (Jul 1991). "Deregulation of a homeobox gene, HOX11, by the t(10;14) in T cell leukemia". Science. 253 (5015): 79–82. doi:10.1126/science.1676542. PMID 1676542.
^ McAlpine PJ, Shows TB (Jul 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
^ "Entrez Gene: TLX1 T-cell leukemia homeobox 1".
^ Kennedy MA, Gonzalez-Sarmiento R, Kees UR, Lampert F, Dear N, Boehm T, Rabbitts TH (Oct 1991). "HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24". Proceedings of the National Academy of Sciences of the United States of America. 88 (20): 8900–4. doi:10.1073/pnas.88.20.8900. PMC 52618. PMID 1681546.
^ Dubé ID, Kamel-Reid S, Yuan CC, Lu M, Wu X, Corpus G, Raimondi SC, Crist WM, Carroll AJ, Minowada J (Dec 1991). "A novel human homeobox gene lies at the chromosome 10 breakpoint in lymphoid neoplasias with chromosomal translocation t(10;14)". Blood. 78 (11): 2996–3003. doi:10.1182/blood.V78.11.2996.2996. PMID 1683261.
^ ^a ^b ^c Kawabe T, Muslin AJ, Korsmeyer SJ (Jan 1997). "HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint". Nature. 385 (6615): 454–8. doi:10.1038/385454a0. PMID 9009195. S2CID 608633.

추가 정보

Allen TD, Zhu YX, Hawley TS, Hawley RG (Oct 2000). "TALE homeoproteins as HOX11-interacting partners in T-cell leukemia". Leukemia & Lymphoma. 39 (3–4): 241–56. doi:10.3109/10428190009065824. PMID 11342305. S2CID 27407074.
Lu M, Zhang N, Ho AD (Jul 1992). "Genomic organization of the putative human homeobox proto-oncogene HOX-11 (TCL-3) and its endogenous expression in T cells". Oncogene. 7 (7): 1325–30. PMID 1352396.
Kennedy MA, Gonzalez-Sarmiento R, Kees UR, Lampert F, Dear N, Boehm T, Rabbitts TH (Oct 1991). "HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24". Proceedings of the National Academy of Sciences of the United States of America. 88 (20): 8900–4. doi:10.1073/pnas.88.20.8900. PMC 52618. PMID 1681546.
Lu M, Gong ZY, Shen WF, Ho AD (Oct 1991). "The tcl-3 proto-oncogene altered by chromosomal translocation in T-cell leukemia codes for a homeobox protein". The EMBO Journal. 10 (10): 2905–10. doi:10.1002/j.1460-2075.1991.tb07840.x. PMC 453003. PMID 1717256.
Dear TN, Colledge WH, Carlton MB, Lavenir I, Larson T, Smith AJ, Warren AJ, Evans MJ, Sofroniew MV, Rabbitts TH (Sep 1995). "The Hox11 gene is essential for cell survival during spleen development". Development. 121 (9): 2909–15. doi:10.1242/dev.121.9.2909. PMID 7555717.
Dear TN, Sanchez-Garcia I, Rabbitts TH (May 1993). "The HOX11 gene encodes a DNA-binding nuclear transcription factor belonging to a distinct family of homeobox genes". Proceedings of the National Academy of Sciences of the United States of America. 90 (10): 4431–5. doi:10.1073/pnas.90.10.4431. PMC 46525. PMID 8099440.
Kawabe T, Muslin AJ, Korsmeyer SJ (Jan 1997). "HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint". Nature. 385 (6615): 454–8. doi:10.1038/385454a0. PMID 9009195. S2CID 608633.
Brake RL, Kees UR, Watt PM (Oct 1998). "Multiple negative elements contribute to repression of the HOX11 proto-oncogene". Oncogene. 17 (14): 1787–95. doi:10.1038/sj.onc.1202078. PMID 9778044.
Zhang N, Shen W, Hawley RG, Lu M (Apr 1999). "HOX11 interacts with CTF1 and mediates hematopoietic precursor cell immortalization". Oncogene. 18 (13): 2273–9. doi:10.1038/sj.onc.1202545. PMID 10327073.
Watt PM, Ranford PR, Kees UR (Jun 1999). "Sequence of 10q24 locus surrounding the HOX11 oncogene reveals a new gene HUG1 expressed in a T-ALL cell line". Gene. 234 (1): 169–76. doi:10.1016/S0378-1119(99)00157-2. PMID 10393251.
Brake RL, Kees UR, Watt PM (May 2002). "A complex containing PBX2 contributes to activation of the proto-oncogene HOX11". Biochemical and Biophysical Research Communications. 294 (1): 23–34. doi:10.1016/S0006-291X(02)00426-6. PMID 12054735.
Bodenmiller DM, Baxter CS, Hansen DV, Potter SS (Apr 2002). "Phylogenetic analysis of Hoxa 11 sequences reveals absence of transposable elements, conservation of transcription factor binding sites, and suggests antisense coding function". DNA Sequence. 13 (2): 77–83. doi:10.1080/10425170290029981. PMID 12180349. S2CID 38713800.
Cavé H, Suciu S, Preudhomme C, Poppe B, Robert A, Uyttebroeck A, Malet M, Boutard P, Benoit Y, Mauvieux L, Lutz P, Méchinaud F, Grardel N, Mazingue F, Dupont M, Margueritte G, Pages MP, Bertrand Y, Plouvier E, Brunie G, Bastard C, Plantaz D, Vande Velde I, Hagemeijer A, Speleman F, Lessard M, Otten J, Vilmer E, Dastugue N (Jan 2004). "Clinical significance of HOX11L2 expression linked to t(5;14)(q35;q32), of HOX11 expression, and of SIL-TAL fusion in childhood T-cell malignancies: results of EORTC studies 58881 and 58951". Blood. 103 (2): 442–50. doi:10.1182/blood-2003-05-1495. PMID 14504110.
Hoffmann K, Dixon DN, Greene WK, Ford J, Taplin R, Kees UR (Dec 2004). "A microarray model system identifies potential new target genes of the proto-oncogene HOX11". Genes, Chromosomes & Cancer. 41 (4): 309–20. doi:10.1002/gcc.20104. PMID 15384172. S2CID 19475690.
Riz I, Hawley RG (Aug 2005). "G1/S transcriptional networks modulated by the HOX11/TLX1 oncogene of T-cell acute lymphoblastic leukemia". Oncogene. 24 (36): 5561–75. doi:10.1038/sj.onc.1208727. PMC 2408753. PMID 15897879.
Heidari M, Rice KL, Phillips JK, Kees UR, Greene WK (Feb 2006). "The nuclear oncoprotein TLX1/HOX11 associates with pericentromeric satellite 2 DNA in leukemic T-cells". Leukemia. 20 (2): 304–12. doi:10.1038/sj.leu.2404071. PMID 16357834.
Chen E, Lim MS, Rosic-Kablar S, Liu J, Jolicoeur P, Dubé ID, Hough MR (Apr 2006). "Dysregulated expression of mitotic regulators is associated with B-cell lymphomagenesis in HOX11-transgenic mice". Oncogene. 25 (18): 2575–87. doi:10.1038/sj.onc.1209285. PMID 16407851.

인간 10번 염색체의 유전자에 대한 이 기사는 뭉툭한 것이다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000107807 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000025215 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1676542-5] Hatano M, Roberts CW, Minden M, Crist WM, Korsmeyer SJ (Jul 1991). "Deregulation of a homeobox gene, HOX11, by the t(10;14) in T cell leukemia". Science. 253 (5015): 79–82. doi:10.1126/science.1676542. PMID 1676542.

[pmid1973146-6] McAlpine PJ, Shows TB (Jul 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.

[entrez-7] "Entrez Gene: TLX1 T-cell leukemia homeobox 1".

[8] Kennedy MA, Gonzalez-Sarmiento R, Kees UR, Lampert F, Dear N, Boehm T, Rabbitts TH (Oct 1991). "HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24". Proceedings of the National Academy of Sciences of the United States of America. 88 (20): 8900–4. doi:10.1073/pnas.88.20.8900. PMC 52618. PMID 1681546.

[9] Dubé ID, Kamel-Reid S, Yuan CC, Lu M, Wu X, Corpus G, Raimondi SC, Crist WM, Carroll AJ, Minowada J (Dec 1991). "A novel human homeobox gene lies at the chromosome 10 breakpoint in lymphoid neoplasias with chromosomal translocation t(10;14)". Blood. 78 (11): 2996–3003. doi:10.1182/blood.V78.11.2996.2996. PMID 1683261.

[pmid9009195-10] Kawabe T, Muslin AJ, Korsmeyer SJ (Jan 1997). "HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint". Nature. 385 (6615): 454–8. doi:10.1038/385454a0. PMID 9009195. S2CID 608633.

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TLX1

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