MXI1

MXI1
식별자
에일리어스	MXI1, MAD2, MXD2, MXI, bHLHc11, MAX 인터랙터1, 이합체단백질
외부 ID	OMIM: 600020 MGI: 97245 HomoloGene: 4351 GenCard: MXI1
유전자 위치(인간)
크르.	10번 염색체(인간)
끝.	110,287,190 bp
유전자 위치(마우스)
크르.	19번 염색체(쥐)
끝.	53,364,241 bp
RNA발현패턴
	상단 표시 위치:
	시신경; ; 아킬레스건; ; 뇌량; ; 미주신경의 하부 신경절; ; 결석골; ; 이하선; ; 중전두회; ; 시상하핵; ; 외이성 망막; ; 후중심회;
	상단 표시 위치:
	피; ; 소뇌충; ; 어금니; ; 중앙 융기; ; 후상피; ; 폰틴핵; ; 내측 유전핵; ; 정낭포; ; 하등 콜로큘러스; ; 적란 세포;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 존재론
분자 함수	DNA결합; 단백질 결합; 단백질 이량화 활성; 전사 코어프레서 활성; RNA중합효소II전사조절영역배열특이적DNA결합; DNA결합전사억제제활성, RNA중합효소II 특이적; DNA결합전사인자활성, RNA중합효소II 특이적;
셀룰러 컴포넌트	핵소체; 핵; 세포; RNA중합효소II전사조절복합체;
생물학적 과정	전사인자의 세포질 분리; 전사조절, DNA템플릿화; 전사, DNA 템플릿; 세포군 증식의 음성 조절; RNA중합효소II에 의한 전사 음성 조절;
	출처:아미고 / QuickGO
맞춤법
	4601
	17859
	ENSG00000119950
	ENSMUSG000025025
	P50539
	P50540
	NM_130439; NM_001008541; NM_005962
NM_001008542; NM_001008543; NM_010847; NM_001360345; NM_001360346;
	NM_001360347; NM_001360348
	NP_001008541; NP_005953; NP_569157
NP_001008542; NP_001008543; NP_034977; NP_001347274; NP_001347275;
	NP_001347276; NP_001347277
	위키데이터
인간 보기/편집	마우스 표시/편집

MAX-상호작용단백질 1은 ^[5]^[6]MXI1유전자에 의해 인체 내에서 부호화되는 단백질이다.

기능.

발암성 전사 인자를 생성하는 c-myc 유전자의 발현은 정상 세포에서는 엄격하게 규제되지만 인간 암에서는 종종 규제 해제된다.이 유전자에 의해 암호화된 단백질은 MYC 기능을 부정적으로 조절하는 것으로 생각되는 전사 억제제이며, 따라서 잠재적 종양 억제제이다.이 단백질은 MYC에 결합하고 그 기능에 필요한 또 다른 염기성 나선형 단백질인 MAX를 위해 경쟁함으로써 MYC의 전사 활성을 억제한다.이 유전자의 결함은 전립선 종양 환자들에게서 자주 발견된다.서로 다른 Isoform을 코드하는 세 개의 대체 스플라이스된 트랜스크립트가 설명되었다.대체적으로 스플라이스된 추가 트랜스크립트가 존재할 수 있지만 이러한 트랜스크립트의 산물은 실험적으로 ^[6]검증되지 않았다.

상호 작용

MXI1은 SMC3 및 ^[7]^[8]^[9]^[10]^[11]MAX와 상호^[7] 작용하는 것으로 나타났습니다.

레퍼런스

^ ^a ^b ^c GRCh38: 앙상블 릴리즈 89: ENSG00000119950 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리즈 89: ENSMUSG000025025 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wechsler DS, Hawkins AL, Li X, Jabs EW, Griffin CA, Dang CV (Nov 1994). "Localization of the human Mxi1 transcription factor gene (MXI1) to chromosome 10q24-q25". Genomics. 21 (3): 669–72. doi:10.1006/geno.1994.1336. PMID 7959753.
^ ^a ^b "Entrez Gene: MXI1 MAX interactor 1".
^ ^a ^b Gupta K, Anand G, Yin X, Grove L, Prochownik EV (Mar 1998). "Mmip1: a novel leucine zipper protein that reverses the suppressive effects of Mad family members on c-myc". Oncogene. 16 (9): 1149–59. doi:10.1038/sj.onc.1201634. PMID 9528857.
^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
^ Billin AN, Eilers AL, Queva C, Ayer DE (Dec 1999). "Mlx, a novel Max-like BHLHZip protein that interacts with the Max network of transcription factors". J. Biol. Chem. 274 (51): 36344–50. doi:10.1074/jbc.274.51.36344. PMID 10593926.
^ Meroni G, Reymond A, Alcalay M, Borsani G, Tanigami A, Tonlorenzi R, Lo Nigro C, Messali S, Zollo M, Ledbetter DH, Brent R, Ballabio A, Carrozzo R (May 1997). "Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor". EMBO J. 16 (10): 2892–906. doi:10.1093/emboj/16.10.2892. PMC 1169897. PMID 9184233.
^ FitzGerald MJ, Arsura M, Bellas RE, Yang W, Wu M, Chin L, Mann KK, DePinho RA, Sonenshein GE (Apr 1999). "Differential effects of the widely expressed dMax splice variant of Max on E-box vs initiator element-mediated regulation by c-Myc". Oncogene. 18 (15): 2489–98. doi:10.1038/sj.onc.1202611. PMID 10229200.

추가 정보

Zervos AS, Gyuris J, Brent R (1993). "Mxi1, a protein that specifically interacts with Max to bind Myc-Max recognition sites". Cell. 72 (2): 223–32. doi:10.1016/0092-8674(93)90662-A. PMID 8425219. S2CID 5146555.
Zervos AS, Gyuris J, Brent R (1994). "Mxi1, a protein that specifically interacts with Max to bind Myc-Max recognition sites" (PDF). Cell. 79 (2): following 388. PMID 7954804. Archived from the original (PDF) on 2011-09-28.
Schreiber-Agus N, Meng Y, Hoang T, Hou H, Chen K, Greenberg R, Cordon-Cardo C, Lee HW, DePinho RA (1998). "Role of Mxi1 in ageing organ systems and the regulation of normal and neoplastic growth". Nature. 393 (6684): 483–7. Bibcode:1998Natur.393..483S. doi:10.1038/31008. PMID 9624006. S2CID 4387311.
Eagle LR, Yin X, Brothman AR, Williams BJ, Atkin NB, Prochownik EV (1995). "Mutation of the MXI1 gene in prostate cancer". Nat. Genet. 9 (3): 249–55. doi:10.1038/ng0395-249. PMID 7773287. S2CID 32569637.
Albarosa R, DiDonato S, Finocchiaro G (1995). "Redefinition of the coding sequence of the MXI1 gene and identification of a polymorphic repeat in the 3' non-coding region that allows the detection of loss of heterozygosity of chromosome 10q25 in glioblastomas". Hum. Genet. 95 (6): 709–11. doi:10.1007/BF00209493. PMID 7789959. S2CID 303145.
Schreiber-Agus N, Chin L, Chen K, Torres R, Rao G, Guida P, Skoultchi AI, DePinho RA (1995). "An amino-terminal domain of Mxi1 mediates anti-Myc oncogenic activity and interacts with a homolog of the yeast transcriptional repressor SIN3". Cell. 80 (5): 777–86. doi:10.1016/0092-8674(95)90356-9. PMID 7889571. S2CID 6210262.
Edelhoff S, Ayer DE, Zervos AS, Steingrímsson E, Jenkins NA, Copeland NG, Eisenman RN, Brent R, Disteche CM (1994). "Mapping of two genes encoding members of a distinct subfamily of MAX interacting proteins: MAD to human chromosome 2 and mouse chromosome 6, and MXI1 to human chromosome 10 and mouse chromosome 19". Oncogene. 9 (2): 665–8. PMID 8290278.
Wechsler DS, Shelly CA, Dang CV (1997). "Genomic organization of human MXI1, a putative tumor suppressor gene". Genomics. 32 (3): 466–70. doi:10.1006/geno.1996.0144. PMID 8838813.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Shimizu E, Shirasawa H, Kodama K, Sato T, Simizu B (1997). "Expression, regulation and polymorphism of the mxi1 genes". Gene. 176 (1–2): 45–8. doi:10.1016/0378-1119(96)00206-5. PMID 8918230.
Gupta K, Anand G, Yin X, Grove L, Prochownik EV (1998). "Mmip1: a novel leucine zipper protein that reverses the suppressive effects of Mad family members on c-myc". Oncogene. 16 (9): 1149–59. doi:10.1038/sj.onc.1201634. PMID 9528857.
Prochownik EV, Eagle Grove L, Deubler D, Zhu XL, Stephenson RA, Rohr LR, Yin X, Brothman AR (1999). "Commonly occurring loss and mutation of the MXI1 gene in prostate cancer". Genes Chromosomes Cancer. 22 (4): 295–304. doi:10.1002/(SICI)1098-2264(199808)22:4<295::AID-GCC5>3.0.CO;2-Q. PMID 9669667.
Li XJ, Wang DY, Zhu Y, Guo RJ, Wang XD, Lubomir K, Mukai K, Sasaki H, Yoshida H, Oka T, Machinami R, Shinmura K, Tanaka M, Sugimura H (1999). "Mxi1 mutations in human neurofibrosarcomas". Jpn. J. Cancer Res. 90 (7): 740–6. doi:10.1111/j.1349-7006.1999.tb00809.x. PMC 5926139. PMID 10470286.
Benson LQ, Coon MR, Krueger LM, Han GC, Sarnaik AA, Wechsler DS (1999). "Expression of MXI1, a Myc antagonist, is regulated by Sp1 and AP2". J. Biol. Chem. 274 (40): 28794–802. doi:10.1074/jbc.274.40.28794. PMID 10497252.
Taj MM, Tawil RJ, Engstrom LD, Zeng Z, Hwang C, Sanda MG, Wechsler DS (2001). "Mxi1, a Myc antagonist, suppresses proliferation of DU145 human prostate cells" (PDF). Prostate. 47 (3): 194–204. doi:10.1002/pros.1063. hdl:2027.42/34758. PMID 11351349. S2CID 27372396.
Yin X, Landay MF, Han W, Levitan ES, Watkins SC, Levenson RM, Farkas DL, Prochownik EV (2001). "Dynamic in vivo interactions among Myc network members". Oncogene. 20 (34): 4650–64. doi:10.1038/sj.onc.1204606. PMID 11498788.
Manni I, Tunici P, Cirenei N, Albarosa R, Colombo BM, Roz L, Sacchi A, Piaggio G, Finocchiaro G (2002). "Mxi1 inhibits the proliferation of U87 glioma cells through down-regulation of cyclin B1 gene expression". Br. J. Cancer. 86 (3): 477–84. doi:10.1038/sj.bjc.6600065. PMC 2375210. PMID 11875718.
Ariyanayagam-Baksh SM, Baksh FK, Swalsky PA, Finkelstein SD (2004). "Loss of heterozygosity in the MXI1 gene is a frequent occurrence in melanoma". Mod. Pathol. 16 (10): 992–5. doi:10.1097/01.MP.0000087421.44975.1C. PMID 14559981.

외부 링크

MXI1+단백질+미국 국립의학도서관의 의학 과목 제목(MeSH)
팩터북 Mxi1

이 기사에는 미국 국립 의학 도서관(미국 국립 의학 도서관)의 공공 도메인 텍스트가 포함되어 있습니다.

인간 10번 염색체의 유전자에 대한 이 기사는 뭉툭한 것이다.위키피디아를 확장함으로써 위키피디아를 도울 수 있습니다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리즈 89: ENSG00000119950 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리즈 89: ENSMUSG000025025 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7959753-5] Wechsler DS, Hawkins AL, Li X, Jabs EW, Griffin CA, Dang CV (Nov 1994). "Localization of the human Mxi1 transcription factor gene (MXI1) to chromosome 10q24-q25". Genomics. 21 (3): 669–72. doi:10.1006/geno.1994.1336. PMID 7959753.

[entrez-6] "Entrez Gene: MXI1 MAX interactor 1".

[pmid9528857-7] Gupta K, Anand G, Yin X, Grove L, Prochownik EV (Mar 1998). "Mmip1: a novel leucine zipper protein that reverses the suppressive effects of Mad family members on c-myc". Oncogene. 16 (9): 1149–59. doi:10.1038/sj.onc.1201634. PMID 9528857.

[pmid16189514-8] Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

[pmid10593926-9] Billin AN, Eilers AL, Queva C, Ayer DE (Dec 1999). "Mlx, a novel Max-like BHLHZip protein that interacts with the Max network of transcription factors". J. Biol. Chem. 274 (51): 36344–50. doi:10.1074/jbc.274.51.36344. PMID 10593926.

[pmid9184233-10] Meroni G, Reymond A, Alcalay M, Borsani G, Tanigami A, Tonlorenzi R, Lo Nigro C, Messali S, Zollo M, Ledbetter DH, Brent R, Ballabio A, Carrozzo R (May 1997). "Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor". EMBO J. 16 (10): 2892–906. doi:10.1093/emboj/16.10.2892. PMC 1169897. PMID 9184233.

[pmid10229200-11] FitzGerald MJ, Arsura M, Bellas RE, Yang W, Wu M, Chin L, Mann KK, DePinho RA, Sonenshein GE (Apr 1999). "Differential effects of the widely expressed dMax splice variant of Max on E-box vs initiator element-mediated regulation by c-Myc". Oncogene. 18 (15): 2489–98. doi:10.1038/sj.onc.1202611. PMID 10229200.

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MXI1

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기능.

상호 작용

레퍼런스

추가 정보

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