호모 사피엔스 종의 단백질 코드 유전자
CREBL1이라고 도 알려진 CAMP 응답성 요소 결합 단백질 유사 1은 CREBL1 [5] [6] 단백질 이다.
기능. 이 유전자에 의해 암호화된 단백질은 전사 인자 의 bZip 슈퍼패밀리의 Creb /ATF 서브패밀리와 배열 유사성을 가진다.세포질 과 핵 둘 다에 위치해요이 유전자는 [5] 염색체 의 주요 조직적합성 복합체(MHC) 등급 III 영역에 국한된다.
레퍼런스 ^ a b c ENSG00000228628, ENSG00000234539, ENSG00000168468 GRCh38: Ensubl 릴리스 89: ENSG00000213676, ENSG00000228628, ENSG00000234539, ENSG00000168468 - Ensubl , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000015461 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b "Entrez Gene: CREBL1 cAMP responsive element binding protein-like 1" .^ Haze K, Okada T, Yoshida H, Yanagi H, Yura T, Negishi M, Mori K (April 2001). "Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response" . Biochem. J . 355 (Pt 1): 19–28. doi :10.1042/0264-6021:3550019 . PMC 1221707 PMID 11256944 .
추가 정보 Bristow J, Tee MK, Gitelman SE, et al. (1993). "Tenascin-X: a novel extracellular matrix protein encoded by the human XB gene overlapping P450c21B" . J. Cell Biol . 122 (1): 265–78. doi :10.1083/jcb.122.1.265 . PMC 2119596 PMID 7686164 . Min J, Shukla H, Kozono H, et al. (1996). "A novel Creb family gene telomeric of HLA-DRA in the HLA complex". Genomics . 30 (2): 149–56. doi :10.1006/geno.1995.9891 . PMID 8586413 . Khanna A, Campbell RD (1996). "The gene G13 in the class III region of the human MHC encodes a potential DNA-binding protein" . Biochem. J . 319. ( Pt 1): 81–9. doi :10.1042/bj3190081 . PMC 1217738 PMID 8870652 . Speek M, Barry F, Miller WL (1997). "Alternate promoters and alternate splicing of human tenascin-X, a gene with 5' and 3' ends buried in other genes" . Hum. Mol. Genet . 5 (11): 1749–58. doi :10.1093/hmg/5.11.1749 PMID 8923003 . Swanson DJ, Adachi M, Lewis EJ (2000). "The homeodomain protein Arix promotes protein kinase A-dependent activation of the dopamine beta-hydroxylase promoter through multiple elements and interaction with the coactivator cAMP-response element-binding protein-binding protein" . J. Biol. Chem . 275 (4): 2911–23. doi :10.1074/jbc.275.4.2911 PMID 10644760 . Yoshida H, Okada T, Haze K, et al. (2001). "Endoplasmic reticulum stress-induced formation of transcription factor complex ERSF including NF-Y (CBF) and activating transcription factors 6alpha and 6beta that activates the mammalian unfolded protein response" . Mol. Cell. Biol . 21 (4): 1239–48. doi :10.1128/MCB.21.4.1239-1248.2001 . PMC 99577 PMID 11158310 . Ye J, Rawson RB, Komuro R, et al. (2001). "ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs" . Mol. Cell . 6 (6): 1355–64. doi :10.1016/S1097-2765(00)00133-7 PMID 11163209 . Haze K, Okada T, Yoshida H, et al. (2001). "Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response" . Biochem. J . 355 (Pt 1): 19–28. doi :10.1042/0264-6021:3550019 . PMC 1221707 PMID 11256944 . Tong WY, Nagano-Fujii M, Hidajat R, et al. (2003). "Physical interaction between hepatitis C virus NS4B protein and CREB-RP/ATF6beta" (PDF) . Biochem. Biophys. Res. Commun . 299 (3): 366–72. doi :10.1016/S0006-291X(02)02638-4 . PMID 12445808 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Okada T, Haze K, Nadanaka S, et al. (2003). "A serine protease inhibitor prevents endoplasmic reticulum stress-induced cleavage but not transport of the membrane-bound transcription factor ATF6" . J. Biol. Chem . 278 (33): 31024–32. doi :10.1074/jbc.M300923200 PMID 12782636 . Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6" . Nature . 425 (6960): 805–11. Bibcode :2003Natur.425..805M . doi :10.1038/nature02055 PMID 14574404 . Xie T, Rowen L, Aguado B, et al. (2004). "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse" . Genome Res . 13 (12): 2621–36. doi :10.1101/gr.1736803 . PMC 403804 PMID 14656967 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . 외부 링크 이 기사에는 미국 국립 의학 도서관 (미국 국립 의학 도서관 )의 공공 도메인 텍스트가 포함되어 있습니다.
(1) 기본 도메인
(1.1 ) 베이직 류신 지퍼(bZIP )(1.2) 기본나선-루프-나선 (bHLH )
그룹 A 그룹 B 그룹 C bHLH-PAS 그룹 D 그룹 E 그룹 F bHLH-COE
(1.3) bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) 기본나선경간나선(bHSH)
(2.1) 핵수용체 (CYS4 )
서브패밀리 1 서브패밀리 2 서브 패밀리 3 서브패밀리 4 서브패밀리 5 서브패밀리 6 서브패밀리 0
(2.2) 기타 CY4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) 교대 조성 (2.6) WRKY