NFYB
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| 식별자 | |||||||||||||||||||||||||||||||||||||||||||||||||||
| 에일리어스 | NFYB, CBF-A, CBF-B, HAP3, NF-YB, 핵전사인자 Y 서브유닛 베타 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| 외부 ID | OMIM : 189904 MGI : 97317 HomoloGene : 38149 GenCard : NFYB | ||||||||||||||||||||||||||||||||||||||||||||||||||
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핵전사인자 Y 서브유닛 베타는 인간의 NFYB [5][6]유전자에 의해 암호화되는 단백질이다.
기능.
이 유전자에 의해 코드된 단백질은 삼량체 복합체의 서브유닛으로, 다양한 유전자에서 프로모터 영역의 CCAAT 모티브에 높은 특이성으로 결합하는 고도로 보존된 전사인자를 형성한다.이 유전자 생성물인 서브유닛 B는 서브유닛 A 결합의 전제조건인 C 서브유닛과 긴밀한 이합체를 형성한다.생성된 삼량체는 높은 특이성과 친화성으로 DNA에 결합합니다.서브유닛 B, C는 각각 히스톤 모양의 모티브를 포함한다.이러한 서브유닛의 히스톤 성질에 대한 관찰은 단백질 배열 정렬과 [7]돌연변이에 대한 실험이라는 두 가지 유형의 증거에 의해 뒷받침된다.
상호 작용
NFYB는 다음과 상호작용하는 것으로 나타났습니다.
레퍼런스
- ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000120837 - 앙상블, 2017년 5월
- ^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000020248 - 앙상블, 2017년 5월
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Li XY, Mattei MG, Zaleska-Rutczynska Z, Hooft van Huijsduijnen R, Figueroa F, Nadeau J, Benoist C, Mathis D (Mar 1992). "One subunit of the transcription factor NF-Y maps close to the major histocompatibility complex in murine and human chromosomes". Genomics. 11 (3): 630–4. doi:10.1016/0888-7543(91)90070-U. PMID 1774067.
- ^ Maity SN, de Crombrugghe B (Jun 1998). "Role of the CCAAT-binding protein CBF/NF-Y in transcription". Trends Biochem Sci. 23 (5): 174–8. doi:10.1016/S0968-0004(98)01201-8. PMID 9612081.
- ^ "Entrez Gene: NFYB nuclear transcription factor Y, beta".
- ^ Imbriano C, Bolognese F, Gurtner A, Piaggio G, Mantovani R (Jul 2001). "HSP-CBF is an NF-Y-dependent coactivator of the heat shock promoters CCAAT boxes". J. Biol. Chem. 276 (28): 26332–9. doi:10.1074/jbc.M101553200. PMID 11306579.
- ^ Pise-Masison CA, Dittmer J, Clemens KE, Brady JN (Mar 1997). "Physical and functional interaction between the human T-cell lymphotropic virus type 1 Tax1 protein and the CCAAT binding protein NF-Y". Mol. Cell. Biol. 17 (3): 1236–43. doi:10.1128/mcb.17.3.1236. PMC 231848. PMID 9032250.
- ^ Izumi H, Molander C, Penn LZ, Ishisaki A, Kohno K, Funa K (Apr 2001). "Mechanism for the transcriptional repression by c-Myc on PDGF beta-receptor". J. Cell Sci. 114 (Pt 8): 1533–44. doi:10.1242/jcs.114.8.1533. PMID 11282029.
- ^ Bellorini M, Lee DK, Dantonel JC, Zemzoumi K, Roeder RG, Tora L, Mantovani R (Jun 1997). "CCAAT binding NF-Y-TBP interactions: NF-YB and NF-YC require short domains adjacent to their histone fold motifs for association with TBP basic residues". Nucleic Acids Res. 25 (11): 2174–81. doi:10.1093/nar/25.11.2174. PMC 146709. PMID 9153318.
추가 정보
- Lloberas J, Soler C, Celada A (1998). "Repression mechanisms of the I-A beta gene of the major histocompatibility complex". Immunobiology. 198 (1–3): 249–63. doi:10.1016/s0171-2985(97)80045-9. PMID 9442396.
- Mantovani R (1999). "The molecular biology of the CCAAT-binding factor NF-Y". Gene. 239 (1): 15–27. doi:10.1016/S0378-1119(99)00368-6. PMID 10571030.
- Li XY, Mantovani R, Hooft van Huijsduijnen R, Andre I, Benoist C, Mathis D (1992). "Evolutionary variation of the CCAAT-binding transcription factor NF-Y". Nucleic Acids Res. 20 (5): 1087–91. doi:10.1093/nar/20.5.1087. PMC 312095. PMID 1549471.
- Li XY, Hooft van Huijsduijnen R, Mantovani R, Benoist C, Mathis D (1992). "Intron-exon organization of the NF-Y genes. Tissue-specific splicing modifies an activation domain". J. Biol. Chem. 267 (13): 8984–90. doi:10.1016/S0021-9258(19)50377-5. PMID 1577736.
- Lloberas J, Maki RA, Celada A (1995). "Repression of major histocompatibility complex I-A beta gene expression by dbpA and dbpB (mYB-1) proteins". Mol. Cell. Biol. 15 (9): 5092–9. doi:10.1128/mcb.15.9.5092. PMC 230756. PMID 7651426.
- Chang ZF, Liu CJ (1994). "Human thymidine kinase CCAAT-binding protein is NF-Y, whose A subunit expression is serum-dependent in human IMR-90 diploid fibroblasts". J. Biol. Chem. 269 (27): 17893–8. doi:10.1016/S0021-9258(17)32393-1. PMID 8027044.
- Mantovani R, Li XY, Pessara U, Hooft van Huisjduijnen R, Benoist C, Mathis D (1994). "Dominant negative analogs of NF-YA". J. Biol. Chem. 269 (32): 20340–6. doi:10.1016/S0021-9258(17)31997-X. PMID 8051128.
- Pise-Masison CA, Dittmer J, Clemens KE, Brady JN (1997). "Physical and functional interaction between the human T-cell lymphotropic virus type 1 Tax1 protein and the CCAAT binding protein NF-Y". Mol. Cell. Biol. 17 (3): 1236–43. doi:10.1128/mcb.17.3.1236. PMC 231848. PMID 9032250.
- Bellorini M, Lee DK, Dantonel JC, Zemzoumi K, Roeder RG, Tora L, Mantovani R (1997). "CCAAT binding NF-Y-TBP interactions: NF-YB and NF-YC require short domains adjacent to their histone fold motifs for association with TBP basic residues". Nucleic Acids Res. 25 (11): 2174–81. doi:10.1093/nar/25.11.2174. PMC 146709. PMID 9153318.
- Currie RA (1998). "Functional interaction between the DNA binding subunit trimerization domain of NF-Y and the high mobility group protein HMG-I(Y)". J. Biol. Chem. 272 (49): 30880–8. doi:10.1074/jbc.272.49.30880. PMID 9388234.
- Currie RA (1998). "NF-Y is associated with the histone acetyltransferases GCN5 and P/CAF". J. Biol. Chem. 273 (3): 1430–4. doi:10.1074/jbc.273.3.1430. PMID 9430679.
- Currie RA (1998). "Biochemical characterization of the NF-Y transcription factor complex during B lymphocyte development". J. Biol. Chem. 273 (29): 18220–9. doi:10.1074/jbc.273.29.18220. PMID 9660784.
- Bemark M, Olsson H, Heinegård D, Leanderson T (1998). "Purification and characterization of a protein binding to the SP6 kappa promoter. A potential role for CArG-box binding factor-A in kappa transcription". J. Biol. Chem. 273 (30): 18881–90. doi:10.1074/jbc.273.30.18881. PMID 9668064.
- Faniello MC, Bevilacqua MA, Condorelli G, de Crombrugghe B, Maity SN, Avvedimento VE, Cimino F, Costanzo F (1999). "The B subunit of the CAAT-binding factor NFY binds the central segment of the Co-activator p300". J. Biol. Chem. 274 (12): 7623–6. doi:10.1074/jbc.274.12.7623. PMID 10075648.
- Hake SB, Masternak K, Kammerbauer C, Janzen C, Reith W, Steimle V (2000). "CIITA leucine-rich repeats control nuclear localization, in vivo recruitment to the major histocompatibility complex (MHC) class II enhanceosome, and MHC class II gene transactivation". Mol. Cell. Biol. 20 (20): 7716–25. doi:10.1128/MCB.20.20.7716-7725.2000. PMC 86349. PMID 11003667.
- Liang F, Schaufele F, Gardner DG (2001). "Functional interaction of NF-Y and Sp1 is required for type a natriuretic peptide receptor gene transcription". J. Biol. Chem. 276 (2): 1516–22. doi:10.1074/jbc.M006350200. PMID 11022037.
- Izumi H, Molander C, Penn LZ, Ishisaki A, Kohno K, Funa K (2001). "Mechanism for the transcriptional repression by c-Myc on PDGF beta-receptor". J. Cell Sci. 114 (Pt 8): 1533–44. doi:10.1242/jcs.114.8.1533. PMID 11282029.
외부 링크
- NFYB+단백질, 미국 국립의학도서관 의학 과목 제목(MeSH)의 인간
- 팩터북 NF-YB
이 기사에는 미국 국립 의학 도서관(미국 국립 의학 도서관)의 공공 도메인 텍스트가 포함되어 있습니다.
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