ETS 도메인 함유 단백질 Elk-3 는 사람의 ELK3 [5] [6] 단백질 이다.
이 유전자에 의해 코드된 단백질은 ETS 도메인 전사인자 패밀리와 3원 복합인자(TCF) 서브패밀리의 구성원이다. 이 아군의 단백질은 혈청 반응 인자에 의해 모집되어 혈청 반응 요소에 결합될 때 전사를 조절한다. 이 단백질은 신호 유도 인산화로 활성화된다; 설치류에서의 연구는 Ras가 없을 때는 전사 억제제이지만 Ras가 [6]
상호 작용 ELK3는 TCF3 와 [7] 것 으로 나타났습니다.
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG000001145 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG00000008398 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Shipley J, Sheer D, Dalton S, Treisman R, Patel K (Mar 1995). "Mapping of the human SAP1 (SRF accessory protein 1) gene and SAP2, a gene encoding a related protein, to chromosomal bands 1q32 and 12q23, respectively". Genomics . 23 (3): 710–1. doi :10.1006/geno.1994.1564 . PMID 7851904 . ^ a b "Entrez Gene: ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)" .^ Maira, S M; Wurtz J M; Wasylyk B (Nov 1996). "Net (ERP/SAP2) one of the Ras-inducible TCFs, has a novel inhibitory domain with resemblance to the helix-loop-helix motif" . EMBO J . ENGLAND. 15 (21): 5849–65. doi :10.1002/j.1460-2075.1996.tb00972.x . ISSN 0261-4189 . PMC 452333 PMID 8918463 .
추가 정보 Sharrocks AD, Brown AL, Ling Y, Yates PR (1998). "The ETS-domain transcription factor family". Int. J. Biochem. Cell Biol . 29 (12): 1371–87. doi :10.1016/S1357-2725(97)00086-1 . PMID 9570133 . Wasylyk B, Hagman J, Gutierrez-Hartmann A (1998). "Ets transcription factors: nuclear effectors of the Ras-MAP-kinase signaling pathway". Trends Biochem. Sci . 23 (6): 213–6. doi :10.1016/S0968-0004(98)01211-0 . PMID 9644975 . Price MA, Rogers AE, Treisman R (1995). "Comparative analysis of the ternary complex factors Elk-1, SAP-1a and SAP-2 (ERP/NET)" . EMBO J . 14 (11): 2589–601. doi :10.1002/j.1460-2075.1995.tb07257.x . PMC 398373 PMID 7540136 . Giovane A, Pintzas A, Maira SM, et al. (1994). "Net, a new ets transcription factor that is activated by Ras" . Genes Dev . 8 (13): 1502–13. doi :10.1101/gad.8.13.1502 PMID 7958835 . Maira SM, Wurtz JM, Wasylyk B (1997). "Net (ERP/SAP2) one of the Ras-inducible TCFs, has a novel inhibitory domain with resemblance to the helix-loop-helix motif" . EMBO J . 15 (21): 5849–65. doi :10.1002/j.1460-2075.1996.tb00972.x . PMC 452333 PMID 8918463 . Criqui-Filipe P, Ducret C, Maira SM, Wasylyk B (1999). "Net, a negative Ras-switchable TCF, contains a second inhibition domain, the CID, that mediates repression through interactions with CtBP and de-acetylation" . EMBO J . 18 (12): 3392–403. doi :10.1093/emboj/18.12.3392 . PMC 1171419 PMID 10369679 . Ducret C, Maira SM, Dierich A, Wasylyk B (2000). "The net repressor is regulated by nuclear export in response to anisomycin, UV, and heat shock" . Mol. Cell. Biol . 19 (10): 7076–87. doi :10.1128/mcb.19.10.7076 . PMC 84702 PMID 10490644 . Ducret C, Maira SM, Lutz Y, Wasylyk B (2000). "The ternary complex factor Net contains two distinct elements that mediate different responses to MAP kinase signalling cascades" . Oncogene . 19 (44): 5063–72. doi :10.1038/sj.onc.1203892 PMID 11042694 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Gupta M, Sueblinvong V, Raman J, et al. (2004). "Single-stranded DNA-binding proteins PURalpha and PURbeta bind to a purine-rich negative regulatory element of the alpha-myosin heavy chain gene and control transcriptional and translational regulation of the gene expression. Implications in the repression of alpha-myosin heavy chain during heart failure" . J. Biol. Chem . 278 (45): 44935–48. doi :10.1074/jbc.M307696200 PMID 12933792 . Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins" . Proc. Natl. Acad. Sci. U.S.A . 101 (33): 12130–5. Bibcode :2004PNAS..10112130B . doi :10.1073/pnas.0404720101 PMC 514446 PMID 15302935 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Wasylyk C, Criqui-Filipe P, Wasylyk B (2005). "Sumoylation of the net inhibitory domain (NID) is stimulated by PIAS1 and has a negative effect on the transcriptional activity of Net" . Oncogene . 24 (5): 820–8. doi :10.1038/sj.onc.1208226 PMID 15580297 . Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 . 외부 링크 이 기사에는 미국 국립 의학 도서관 (미국 국립 의학 도서관 )의 공공 도메인 텍스트가 포함되어 있습니다.
(1) 기본 도메인
(1.1 ) 베이직 류신 지퍼(bZIP )(1.2) 기본나선-루프-나선 (bHLH )
그룹 A 그룹 B 그룹 C bHLH-PAS 그룹 D 그룹 E 그룹 F bHLH-COE
(1.3) bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) 기본나선경간나선(bHSH)
(2.1) 핵수용체 (CYS4 )
서브패밀리 1 서브패밀리 2 서브 패밀리 3 서브패밀리 4 서브패밀리 5 서브패밀리 6 서브패밀리 0
(2.2) 기타 CY4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) 교대 조성 (2.6) WRKY